Sera from selected cases of mental retardates were studied for haptoglobin phenotypes (Hp) on polyacrylamide disc gel electro phoresis, No significant alteration in the gene frequencies was observed from the normal control populations in Eastern India. However, a few cases had abnormal patterns which could not be attributed to external factors. An individual with idiopathic mental retardation s...

PURPOSE Eyelid myoclonia and absences (EMA) induced by eye closure associated with brief, fast, and generalized paroxysms of polyspikes and waves was considered as an epileptic syndrome and a type of seizure as well. We analyzed the electroclinical features and evolution of EMA, and tried to determine if it represents a well-defined epileptic syndrome or a non-specific condition associated to o...

This is a case report of a patient with idiopathic gingival hyperplasia and an undiagnosed genetic disorder that demonstrated static encephalopathy, mental retardation, developmental delay, seizures, hypotonia, and severe gingival hypertrophy. The clinical dental management and attempts to obtain a genetic diagnosis are described.

Rett syndrome (RS), a neurological developmental disorder, is one of the commonest causes of cognitive impairment in girls and women. These patients are often initially misdiagnosed as idiopathic mental retardation, cerebral palsy, or autism. Despite several reports from the West, there are very few reports from the Indian population. We present four female children with RS and emphasize the im...

background and purpose: birth of a mentally retarded child is a significant challenge in every family and is associated with the possibility of parental stress and depression. this study aimed to evaluate the self-concept of mothers with educable mentally retarded (emr) children. methods: this cross-sectional study was conducted on 40 mothers with emr children in the only special primary school...

The mental health of the child affects his physical health and the learning process. The present study was conducted to study the health status and etiological factors among 58 mentally challenged children in school for mentally challenged at Sangamner. Majority of mentally challenged children (68.0%) were in 5-9 years age group. Most of them had moderate retardation. (43.0%) In majority of chi...

BACKGROUND Subtelomeric rearrangements contribute to idiopathic mental retardation and human malformations, sometimes as distinct mental retardation syndromes. However, for most subtelomeric defects a characteristic clinical phenotype remains to be elucidated. OBJECTIVE To screen for submicroscopic subtelomeric aberrations using multiplex ligation dependent probe amplification (MLPA). METHO...

Mental retardation affects 2 to 3% of the US population. It is defined by broad criteria, including significantly subaverage intelligence, onset by age 18, and impaired function in a group of adaptive skills. A myriad of genetic and environmental causes have been described, but for approximately half of individuals diagnosed with mental retardation the molecular basis remains unknown. Genomic m...

A screening for submicroscopic rearrangements was performed in 111 patients with idiopathic mental retardation (MR) using fluorescence in situ hybridization (FISH) probes from the subtelomeric regions of all chromosome arms. Ten cryptic rearrangements were found (9%): five de novo deletions; one unbalanced de novo translocation; three unbalanced inherited translocations; and one unbalanced reco...