Prostate cancer (PCa) is the second leading cause of death among men worldwide. Androgen signaling plays key roles in PCa progression [1], and so far available therapeutic agents mainly target androgens or androgen receptor (AR) [2]. However, the patients receiving these treatments often recurs with progression to castration resistant prostate cancer (CRPC) [3]. Metastatic CRPC (mCRPC) is the a...

α-Iso-cubebene (ICB) is a dibenzocyclooctadiene lignin contained in Schisandra chinensis (SC), a well-known medicinal herb that ameliorates cardiovascular symptoms. Thus, we examined the effect of ICB on vascular smooth muscle cell (VSMC) proliferation, a key feature of diverse vascular diseases. When VSMCs primary cultured from rat thoracic aorta were stimulated with PDGF (1-10 ng/ml), cell pr...

Donor cause of death has been suggested to have a significant impact on cardiac transplant morbidity and mortality. Our objective was to evaluate the impact of donor spontaneous intracranial bleeding on clinical outcome after heart transplantation. A group of 160 recipients underwent cardiac transplantation from donors with spontaneous intracranial bleeding (ICB group). These were compared with...

The temperature of Earth's core is a parameter of critical importance to model the thermal structure of Earth. Since the core is mainly made of iron, with a solid liquid boundary (the inner core boundary) at 1220 km from the center of the Earth, the melting temperature of iron at the pressure of the ICB provides constraints on the temperature of the core. These constraints are based either on e...

Immunotherapy has evolved as a new pillar of cancer treatment during the last decade. The main breakthrough was the development of immune checkpoint blocking (ICB) antibodies, which antagonize inhibitory receptors on T cells and their ligands and thus unleash the cellular immune system against the tumor. ICB showed tremendous effects in several types of cancer. However, only a proportion of the...

Tissue-type plasminogen activator (t-PA) is approved for treatment of ischemic stroke patients, but it increases the risk of intracranial bleeding (ICB). Previously, we have shown in a mouse stroke model that stromelysin-1 (matrix metalloproteinase-3 [MMP-3]) induced in endothelial cells was critical for ICB induced by t-PA. In the present study, using bEnd.3 cells, a mouse brain-derived endoth...

After cleavage furrow ingression during cytokinesis, nascent daughter cells remain connected by an intercellular bridge (ICB) and the midbody [1, 2]. The midbody becomes an assembly platform for ESCRT complexes that split apart the plasma membrane (PM) anchored to the ICB and complete abscission, which is the final step of cell division [3-5]. Aurora B governs abscission by regulating its timin...

Immune checkpoint blockade (ICB), which harnesses the body's immune system to recognize and kill cancer cells, has transformed the management landscape for patients with advanced non-small cell lung cancer (NSCLC). Building on the success of this approach, clinical and translational researchers are attempting to augment the benefit of anti-programmed death 1/programmed death ligand 1 monotherap...

Centro de Pesquisas René Rachou-Fiocruz, Av. Augusto de Lima 1715, 30190-002 Belo Horizonte, MG, Brasil *Departamento de Bioquímica e Imunologia, ICB **Departamento de Morfologia, ICB-UFMG, Av. Antonio Carlos 6627, 31270-010 Belo Horizonte, MG Brasil ***Faculdade de Medicina do Triângulo Mineiro, Uberaba, MG, Brasil ****Faculdade de Medicina/Hospital das Clínicas, UFMG, Av. Alfredo Balena 190, ...