Alternative splicing (AS) is one of the most significant components of the functional complexity of human UDP-glucuronosyltransferase enzymes (UGTs), particularly for the UGT1A gene, which represents one of the best examples of a drug-metabolizing gene regulated by AS. Shorter UGT1A isoforms [isoform 2 (i2)] are deficient in glucuronic acid transferase activity but function as negative regulato...

This paper extends the analysis of the relationship between health and schooling by examining the impact of education on the choice of medical care inputs and the subsequent relationship between these inputs and overall health. In particular, we examine the productive effects of education on health as well as the allocative effects of education on the consumption of curative and preventive medi...

Let I1 be a relation structure. We say that I1 is discrete if and only if: (Def. 1) The internal relation of I1 = △the carrier of I1. Let us mention that there exists a poset which is strict discrete and non empty and there exists a poset which is strict discrete and empty. Let X be a set. Then △X is an order in X. Observe that 〈∅,△∅〉 is empty. Let P be an empty relation structure. One can chec...

The necessity of the inclusion second invariant left Cauchy-Green deformation tensor B, namely I2, in strain energy function W rubber-like materials is analysed. Universal relationships that underline such are revisited, and experimental data examined to establish trends variation ?W/?I2. Corroborated by established trends, we consider (meso)structural arguments devise a plausible approach for ...

A macroscopic approximation of RNA secondary structure (Vialette, CPM 2002): • a subsequence of consecutive bases → an interval • a stacked pairing of two disjoint subsequences → a 2interval Three Binary Relations For two 2-intervals D1 = (I1, J1) and D2 = (I2, J2), D1 and D2 are disjoint if the four intervals I1, J1, I2, and J2 are pairwise disjoint. Preceding: D1 < D2 ⇐⇒ I1 < J1 < I2 < J2. Ne...