addition of n-butyl nitrite to isolated rat hepatocytes caused an immediate glutathione depletion followed by an inhibition of mitochondrial respiration, inhi- bition of glycolysis and atp depletion. at cytotoxic butyl nitrite concentrations, lipid  peroxidation  occurred  before  the  plasma  membrane  was  disrupted. cytochrome p-450 inhibitors inhibited peroxynitrite formation and prevented ...

This discussion document is part of a series of reviews of the state of the art in cognitive systems. It was prepared as background material for the Foresight Cognitive Systems Project. The objective of the project is to examine recent progress in two major areas of research – computer science and neuroscience (and their related fields) – and to understand whether progress in understanding cogn...

to develop novel antimycobacterial agents, a new series of thiazolidinone-azole hybrids 4a-b, 5a-b and 6-13 were designed and synthesized. thiazolidin-4-ones (4a-b and 5a-b) were obtained by the reaction of schiff bases and hydrazones (2a-b and 3a-b) with mercaptoacetic acid. 5-benzylidene derivatives (6-13) were gained by treatment of 5a-b with appropriate benzaldehydes according to knoevenage...

purpose the 1-repetition maximum (1-rm) test is the gold standard test for evaluating maximal dynamic strength of groups of muscles. however, safety of actual 1-rm testing is questionable in clinical situations such as type 2 diabetes (t2d), where an estimated 1-rm test is preferred. it is unclear if acceptable test retest reliability exists for the estimated 1-rm test in middle aged t2d patien...

antioxidants are vital substances which possess the ability to protect the body from damage caused by free radical-induced oxidative stress. a variety of free radical scavenging antioxidants exist within the body which many of them are derived from dietary sources like fruits, vegetables and teas. this article describes a test method for screening the antioxidant activity of 60 iranian plants o...

s e l e c t i o n o f a p p r o p r i a t e g r o u n d m o t i o n i s a k e y e l e m e n t w i t h i n a n y s e i s m i c a s s e s s m e n t o f s t r u c t u r e s. m a n y m e t h o d o l o g i e s h a v e b e e n d e v e l o p e d i n o r d e r t o s e l e c t a n d s c a l e g r o u n d m o t i o n r e c o r d s f o r t h e p u r p o s e o f r e s p o n s e h i s t o r y a n a l y s i ...