After myocardial infarction (MI), there is progressive left ventricular (LV) remodeling and impaired exercise capacity. We tested the hypothesis that LV remodeling results in structural and functional changes that determine exercise impairment post-MI. Rats underwent coronary artery ligation (n = 12) or sham (n = 11) surgery followed by serial exercise tests and echocardiography for 16 wk post-...

Ovariectomized Sprague-Dawley (SD) and Wistar rats are widely used as animal models for postmenopausal osteoporosis. This study aimed to investigate differences in the long-term effects of ovariectomy on these two breeds of rats. 6-month-old SD and Wistar rats underwent sham operation (Ssham and Wsham) or bilateral ovariectomy (Sovx and Wovx). Body weight, absolute fat, fifth and sixth lumber v...

BACKGROUND Endothelium-derived nitric oxide (NO) selectively enhances myocardial relaxation and may benefit diastolic function. Left ventricular hypertrophy (LVH) is characterized by abnormal myocardial relaxation and endothelial dysfunction. We investigated endothelium-dependent regulation of LV relaxation in moderate pressure-overload LVH induced by aortic banding in guinea pigs. METHODS AN...

Left ventricular (LV) remodelling following myocardial infarction (MI) is associated with increased morbidity and mortality. Previous data suggest that angiotensin II (Ang II) plays a central role in the molecular events contributing to LV remodelling. We explored the effects of angiotensin-converting-enzyme (ACE) inhibition versus Ang II (AT(1)) receptor blockade on LV remodelling in mice post...

there is no doubt that mowlana is one of the greatest scholars of the islamic world and the most important concept of his intellectual structure is love. love in his opinion is the pillar of contemplation and cannot be described in words. the more he states about love the more light he sheds on it. the objective manifestation of love for him is shams tabrizi. he was the one who changed mowlana ...