نتایج جستجو برای: i receptor

تعداد نتایج: 1572301  

MOHAMMAD H. BOSKABADY , PHILLIP D. SNASHALL,

We have measured the competitive antagonistic effect of chlorpheniramine in bronchi of 8 normal and 12 asthmatic subjects. Classical pharmacological theory states that the degree of competitive antagonism depends only upon 1) antagonist concentration at the receptor, and 2) receptor affinity. Delivery and affinity also influence agonist responsiveness, but measurement of bronchial antagoni...

ژورنال: یافته 2012
شاهسوار, فرهاد, موسوی, طاهره , سابوته, توماج ,

Background : Ankylosing spondylitis (AS) represents a progressive and debilitating disease that affects approximately 0.9% worldwide. So far the precise mechanisms underlying the initiation and progression of AS is still unclear. Linkage between HLA-B27 and AS remains the strongest association between a human leukocyte antigen (HLA) class I molecule and disease. Despite intensive research, the ...

Maryam Ayatollahi Ramin Yaghobi Rozita Zyaie Zeinab Sahraian

Introduction  Insulin-like growth factor I (IGF-I) which is produced in abundance in the normal adult liver, is deeply involved in hepatocyte survival, growth, and differentiation during liver development. IGF-I plays the roles via the receptor (IGF-IR) signaling pathway. IGF-IR unlike IGF-I is expressed strongly in the developing liver, but much more weakly in adults. Objective:  We hypothesi...

Journal: :Journal of Immunology 2023

Abstract The need to rear the offspring necessitated evolution of female’s immune system mount stronger responses than males. One consequence it is that major autoimmune diseases manifest in a sex biased manner with predominance females. However, mechanisms underlying bias have not been clearly defined. We investigated molecular by which male hormones (androgens) regulate αβ T cell function aut...

Journal: :hepatitis monthly 0
yizhong wang department of infectious diseases, shanghai children’s hospital, shanghai jiao tong university, shanghai, china jieliang li department of pathology and laboratory medicine, school of medicine, temple university, philadelphia, usa xu wang department of pathology and laboratory medicine, school of medicine, temple university, philadelphia, usa yu zhou department of pathology and laboratory medicine, school of medicine, temple university, philadelphia, usa ting zhang department of infectious diseases, shanghai children’s hospital, shanghai jiao tong university, shanghai, china; department of pathology and laboratory medicine, school of medicine, temple university, philadelphia, usa. tel: +1-2157072370, e-mail:; ting zhang, department of infectious diseases, shanghai children’s hospital, shanghai jiao tong university, shanghai, china. tel: +86-2152976331 wenzhe ho department of pathology and laboratory medicine, school of medicine, temple university, philadelphia, usa; department of pathology and laboratory medicine, school of medicine, temple university, philadelphia, usa. tel: +1-2157072370, e-mail:; ting zhang, department of infectious diseases, shanghai children’s hospital, shanghai jiao tong university, shanghai, china. tel: +86-2152976331

background macrophages play critical roles in innate immune response in the liver. whether macrophages participate in liver innate immunity against hcv replication is poorly understood objectives the aim of this study was to investigate the role of macrophages in liver innate immunity against hcv replication. conclusions macrophages may play an important role in liver innate immunity against hc...

Journal: :iranian journal of medical sciences 0
s.m. shid moosavi department of physiology, shiraz university of medical sciences, shiraz, iran b. barmaki department of physiology, shiraz university of medical sciences, shiraz, iran b. geramizadeh department of pathology, medical school, shiraz university of medi-cal sciences, shiraz, iran h. fallahzadeh department of pediatrics, nephrol-ogy section, nemazee hospital, shiraz university of medical sciences, shiraz, iran e. j. johns deparment of physiology, university college cork, ireland

background: previous studies have shown increases in endothelin (et) concentration of plasma and renal tissues in acute renal failure (arf).  et has a potent vasoconstrictor effect, through binding with its et a receptors, and may play some roles in renal hemodynamic dysfunction in arf. objective: to examine the beneficial effect of a selective et a -receptor antagonist on renal dysfunction and...

Introduction: Renin angiotensin system has an important role in blood pressure and renal functions. Active angiotensin-converting enzyme 2 converts angiotensin I into angiotensin-(1-7) which is a vasodilator hormone and interacts with nitric oxide changes as well as other angiotensin II receptors. In this study we evaluated the role of Mas receptor antagonist (A779) and renal perfusion press...

Journal: :cell journal 0

objective: ecstasy, also known as 3, 4-methylenedioxymethamphetamine (mdma), is a psychoactive recreational hallucinogenic substance and a major worldwide recreational drug. there are neurotoxic effects observed in laboratory animals and humans following mdma use. mdma causes apoptosis in neurons of the central nervous system (cns). withdrawal signs are attenuated by treatment with the adenosin...

BAHRAM HAGHIGHI, SHAHRAZ TOORI, SHAHREBANOU SHAJARIAN,

The effect of epinephrine on phosphatidate phosphohydrolase (PAP) activity of isolated human hepatocytes was studied. Epineprine inhibited the enzyme activity progressively at concentrations above 0.1 µM, reaching a maximum inhibition of 64.5% at 100 µM concentration. Inclusion of alprenolol, a β-receptor blocker, in the incubation mixture abolished the inhibitory effect of epinephrine on P...

Journal: :iranian journal of pathology 2009
zohreh yousefi shohreh saeed nourieh sharifi maryam bahreini

background and objectives: presence of steroid hormone receptors (estrogen and progesterone) in the tumor tissues of various organs correlates with response to therapy and prognosis. since their role in ovarian cancer is still controversial, in this study we investigated the expression and prognostic value of the estrogen receptor (er) and progesterone receptors (pr) in ovarian papillary serous...

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