Hypopharyngeal cancer (HPC) frequently presents at an advanced stage, resulting in poor prognosis. Although combined surgical therapy and chemoradiotherapy have improved the survival for patients with HPC over the past 3 decades, the mortality rate in late-stage diagnosis of HPC is unsatisfactory. In this study, we performed whole-exome sequencing (WES) of 23 hypopharyngeal tumor and paired adj...

Primary pituitary gland cancer is extremely rare. The current study presents the case of a patient diagnosed with pituitary cancer three months after completing surgery and post-operative chemoradiotherapy for hypopharyngeal cancer. In this report we discuss 57-year-old patient who presented with diplopia and ptosis four months following the completion of treatment for hypopharyngeal cancer. A ...

BACKGROUND AND PURPOSE The size of the primary lesion and the lymph node metastasis are critical indicators for the patient prognosis. Here we attempted to assess the correlation between these 2 prognostic parameters in patients with oropharyngeal, hypopharyngeal, oral, or maxillary sinus cancer. METHODS We retrospectively studied 66 patients with oropharyngeal or hypopharyngeal (n = 24), ora...

OBJECTIVE Hypopharyngeal carcinoma is an aggressive malignancy that usually presents at a late stage, thereby resulting in an overall poor prognosis for these patients. The aim of this study is to determine the evolution and postoperative results of patients treated in our department for hypopharyngeal cancer. METHODS We retrospectively reviewed 60 patients who had undergone surgery followed ...

BACKGROUND Focal adhesion kinase (FAK) plays an important role in tumor metastasis. The purpose of this study was to evaluate the significance of FAK expression in surgically treated patients with hypopharyngeal cancer. METHODS We retrospectively reviewed the clinical charts of patients treated at our institution between 2004 and 2012 and identified 87 patients with hypopharyngeal cancer. FAK...

Introduction For locally advanced-stage laryngeal and hypopharyngeal cancer, the total laryngectomy or laryngopharyngectomy can be an option for primary treatment. This is indicated when a partial resection not achievable while obtaining organ function preservation of its through radiotherapy possible.

introduction: laryngeal cancer is the second most common cancer involving the respiratory tract, second only to lung cancer. previous studies have shown opium dependency to be a possible risk factor for laryngeal cancer. opium consumption is a major problem in some parts of the world. the aim of this study was to investigate the effect of opium consumption on the pattern of involvement in laryn...

Surgical resection is one of the standard therapeutic choices for the treatment of hypopharyngeal cancer, whether or not combined with postoperative radiotherapy. The type of operation depends on the extension of the lesion and the subsites involved and often requires some form of reconstruction. Reconstructive strategies depend on whether the larynx, or part of it, has been preserved. We belie...

Hypopharyngeal cancer is a distinct type of malignant head and neck tumor, which exhibits low sensitivity to anti-cancer drugs. The importance of developing methods for reducing chemotherapy resistance, and improving and enhancing prognosis has previously been emphasized and is considered a challenge for effective clinical treatment of hypopharyngeal cancer. The current study investigated the e...

Introduction: Laryngeal cancer is the second most common cancer involving the respiratory tract, second only to lung cancer. Previous studies have shown opium dependency to be a possible risk factor for laryngeal cancer. Opium consumption is a major problem in some parts of the world. The aim of this study was to investigate the effect of opium consumption on the pattern of involvement in laryn...