The two main non-sedative effects of thalidomide (2-phtalimido-glutarimide) in man are the embryopathy, which finally forced termination of its use as a sedative, and the excellent efficacy in leprosy reactions, alone for whose prevention and treatment the drug is still available. Both effects can be explained on the molecular level by assuming that a non-sedative metabolite of thalidomide medi...

Moderate and deep sedation can be provided using several routes of drug administration including oral (PO), inhalation, and parental injection. The safety and efficacy of these various techniques is largely dependent on pharmacokinetic principles. This continuing education article will highlight essential principles of absorption, distribution, and elimination of commonly used sedative agents.

own lips his opinions of " men and things," could not have been otherwise than struck with his sagacity on all matters to the consideration of which he had directed his able mind. It is Avell known that the subject of insanity was one of Sir H. Halford's favourite topics of study. We well recollect a long and deeply interesting conversation which we had with him, on the various points connected...

STUDY OBJECTIVE Australia has had a two party parliamentary political system for most of the period since its Federation in 1901, dominated either by a social democratic (Labor) or a conservative ideological perspective. This paper investigates whether such political differences at Federal and State levels have influenced suicide rates in the state of New South Wales (NSW) for the period 1901-1...

In search of bioactive molecules in the class of functionally substituted heterocyclic compounds, we synthesized some new N-(1-methyl-1H-pyrazole-4-carbonyl)thiourea derivatives and evaluated their analgesic and sedative effects. The obtained compounds were characterized by elemental analysis, IR and NMR spectroscopic analyses and evaluated for their analgesic and sedative effects.

BACKGROUND The goal of this study was to examine the latent structure among measures of alcohol-induced subjective feelings of intoxication from a behavioral pharmacology perspective. METHODS Data on subjective intoxication, measured concomitantly by the Subjective High Assessment Scale, Biphasic Alcohol Effect Scale, and the Short Version of the Profile of Mood States, were collected at 3 le...

Sedating children for diagnostic and therapeutic procedures remains an area of rapid change and considerable controversy. Exploration of this topic is made difficult by the fact that the reports of techniques and outcomes for pediatric sedation appear in a wide range of subspecialty publications and rarely undergo comprehensive examination. In this review article, we will touch on many aspects ...