In a study designed to determine the protective effect of the specific histamine H1 antagonist terfenadine on hypertonic saline induced bronchoconstriction, 10 asthmatic subjects underwent hypertonic saline challenge (3.6%) after premedication with placebo or terfenadine (120 mg) 12 and two hours before the challenge. Hypertonic saline was administered in a dose dependent manner and the respons...

BACKGROUND AND PURPOSE Hypertonic saline (3% NaCl) infusions can be used to treat acute neurologic hyponatremia (ANH) in critically ill patients with neurological and neurosurgical disorders such as subarachnoid hemorrhage. Adjustments in the rate of hypertonic saline infusions to treat ANH are needed to achieve a goal sodium range and are usually made on an empiric basis. To date, no data are ...

BACKGROUND AND AIMS There is no evidence that the epinephrine-3% hypertonic saline combination is more effective than 3% hypertonic saline alone for treating infants hospitalized with acute bronchiolitis. We evaluated the efficacy of nebulized epinephrine in 3% hypertonic saline. PATIENTS AND METHODS We performed a randomized, double-blind, placebo-controlled clinical trial in 208 infants hos...

Acute kidney injury (AKI) occurs both after traumatic brain injury (TBI) and after hypertonic saline administration; furosemide may be useful in preventing AKI indirectly. Serum neutrophil gelatinase-associated lipocalin (sNGAL) is superior to serum creatinine (sCr) in diagnosing early AKI. We compared the administration of hypertonic saline plus furosemide (HTS+F) versus hypertonic saline (HTS...

BACKGROUND It is an inherent assumption in randomised controlled trials that the drug effect can be estimated by subtracting the response during placebo from the response during active drug treatment. OBJECTIVE To test the assumption of additivity. The primary hypothesis was that the total treatment effect is smaller than the sum of the drug effect and the placebo effect. The secondary hypoth...

Hypertonic saline solution can absorb part of the intracellular fluid volume into the extracellular space. The effects of this solution on the cardiovascular system are increased coronary flow and increased left ventricular contraction, without sympathetic system activation. This study was designed to assess the effects of hypertonic saline solution in open heart surgery and to compare it w...

IN this issue of ANESTHESIOLOGY, Rozet et al. present the findings of a comprehensive study comparing two hyperosmolar agents, hypertonic saline (HS) and mannitol, for brain relaxation during craniotomy. This work calls into question whether sufficient information is now available to advocate substitution of mannitol with HS to promote brain relaxation during routine craniotomy. It was discover...

background: one of the most serious late complications, after evacuation of liver hydatid cyst and instillation of scolicidal agents is sclerosing cholangitis, most probably caused by the type of scolicidal agents instilled.   objective:   to determine the incidence of sclerosing cholangitis after intra-biliary tract infusion of 5% saline and 0.5% silver nitrate.   methods: 5% hypertonic saline...

Acute kidney injury (AKI) occurs both after traumatic brain injury (TBI) and after hypertonic saline administration; furosemide may be useful in preventing AKI indirectly. Serum neutrophil gelatinase-associated lipocalin (sNGAL) is superior to serum creatinine (sCr) in diagnosing early AKI. We compared the administration of hypertonic saline plus furosemide (HTS+F) versus hypertonic saline (HTS...

Hypertonic saline solutions have properties that may be advantageous for resuscitation. In both animal and human studies rapid improvements in cardiovascular status occur when hypertonic saline is administered to hypovolaemic subjects and the possible side effects of hypertonic solutions have not been shown to be of clinical importance. Hypertonic saline certainly has a potential role in resusc...