median cleft is the midline cleft of the lip. it develops due to incomplete or failed fusion of the median nasal prominence. it can present with minimal deformities such as involvement of the vermilion border, or complex clefting of the midline structures and brain. median clefts are broadly classified as true and false clefts. this case report describes a rare case of median cleft of the upper...

BACKGROUND This report documents the authors' experience with 95 hypertelorism corrections performed since 1971. The authors note their findings regarding outcomes, preferred age at surgery, technique, and stability of results with growth. METHODS Patients were classified into three groups: midline clefts (with or without nasal anomalies, Tessier 0 to 14); paramedian clefts (symmetric or asym...

Orbital hypertelorism is an increased distance between the bony orbits and can be caused by frontonasal malformations, craniofacial clefts, frontoethmoidal encephaloceles, glial tumors or dermoid cysts of the root of the nose, and various syndromic or chromosomal disorders. We report a series of 7 cases of hypertelorism that were treated in our hospital. The underlying causes in our series were...

The term 'craniofrontonasal dysplasia' (CFND) was introduced by Cohen' in 1979 when describing a 14 year old girl with coronal craniosynostosis, hypertelorism, limitation of shoulder movement, and digital abnormalities. The child's mother was also affected. In the same volume of Birth Defects, Slover and Sujansky2 reported similar findings in three female sibs, both of whose parents had hyperte...

We present a male infant with hypertelorism, severe myopia and sensorineural deafness, diaphragmatic hernia, and proteinuria. This patient combines features of two distinct genetic conditions, the syndrome of diaphragmatic hernia, exomphalos, absent corpus callosum, hypertelorism, myopia, and sensorineural deafness (MIM 222448), and the facio-oculo-acoustico-renal syndrome (MIM 227290), which i...

LEOPARD multiple congenital anomaly syndrome inherited in an autosomal dominant manner. LEOPARD is an acronym for Lentigines, Eletrocardiographic conduction defects, Ocular hypertelorism, Pulmonary valve stenosis, Abnormalities of the genitalia, Retardation of growth, and Deafness. Clinical diagnosis is primarily based on multiple lentigines, typical facial features, and the presence of hypertr...