The variant form of acute promyelocytic leukaemia (AML-M3) possesses its own characteristic morphology, although usually a few of the cells may have cytoplasmic features of typical AML-M3. In contrast to typical AML-M3, this M3-variant form commonly presents with hyperleucocytosis. As in typical AML-M3, disseminated intravascular coagulopathy (DIVC) occurs in the M3-variant. A boy with this mor...

The patient’s physical examination revealed stridor with diffuse polyphonic crackles on auscultation, normal blood pressure, a rapid and steady heart rate (148 bpm), and low oxyhemoglobin saturation at 90% on the pulse oximeter despite 2 liters per minute of additional oxygen and a 37.5 ° C temperature. Chest X-ray showed, besides a significant known sinistro-convex scoliosis, partial atelectas...

Clinics and pathology Disease De novo ANLL; (one case of blast crisis CML). Phenotype / cell stem origin Mainly M2 or M4, but also M1, M5a, M5b, or M7 ANLL; may be preceded by MDS. Epidemiology About 30 reported cases, mainly found in young adults; children cases are described; median age is about 30 yrs; balanced sex ratio. Clinics Blood data: anemia, thrombocytopenia, mild hyperleucocytosis; ...

Hyperleukocytosis is an oncological emergency but is extremely rare in non-malignant conditions. Nucleated RBCs give rise to spuriously high total leucocyte count and cause clinical dilemma. Thalassemia major patients are known to have leucocytosis even after correction for nucleated RBCs. We report a case of undiagnosed Thalassemia major in a 4 month old infant with total leucocyte count highe...

OBJECTIVE To see the clinical features and treatment of children with Acute Myeloid Leukemia (AML) in Pakistan. SETTING Tertiary referral at a specialist Hematology/Oncology center. METHODS Retrospective, chart-based review of children (less than 14 years) admitted to the hospital with a diagnosis of AML between January 1987 and August 1997. RESULTS A total of 23 patients were admitted. T...