Background & Aim: St John's wort (Hypericum perforatum L.) contains hypericin and hyperforin as the main components of the extract that binds with GABA and sigma opioid receptors. This herb has many pharmacological effects, including analgesic, sedative, soothing, antispasmodic, anticonvulsant, anti-depressant, and anti-bacteria. In this study examined the effect of two concentrations of Hyperi...

The Iowa Center for Research on Botanical Dietary Supplements seeks to optimize Echinacea, Hypericum, and Prunella botanical supplements for human-health benefit, emphasizing antiviral, anti-inflammatory and anti-pain activities. This mini-review reports on ongoing studies on Hypericum. The Center uses the genetically diverse, well-documented Hypericum populations collected and maintained at th...

This special issue on the genus Hypericum (family Hypericaceae) consists of 12 articles focusing on recent advancements related to biosynthetic pathways, biotechnology, molecular biology, genomics, pharmacology, and related disciplines. Hypericum is well-known for its medicinal properties. There are about 487 Hypericum spp., which are distributed across every continent except Antarctica. Althou...

NEDKOV, N., 2007. Research on the Effect of Pre-sowing Treatment on Seed Germination of Hypericum perforatum L. Bulg. J. Agric. Sci., 13: 31-37 Trials were carried out for improvement of seed germination of St. John's Wort (Hypericum perforatum L.) based on studies of main sowing properties after treatments as follows: soaking, soaking and heating and combined seed stratification. Recommendatio...

The active medicinal constituents in Hypericum perforatum, used to treat depression and skin irritation, include flavonoids and xanthones. The carbon skeletons of these compounds are formed by chalcone synthase (CHS) and benzophenone synthase (BPS), respectively. Polyclonal antisera were raised against the polyketide synthases from Hypericum androsaemum and their IgG fractions were isolated. Im...

The essential oils obtained by hydrodistillation from the aerial parts of Hypericum perforatum L. and Hypericum scabrum L. from plants growing wild in Tajikistan were analyzed by GC-MS. Sixty-six compounds were identified in the essential oils of H. perforatum with germacrene D (13.7%), α-pinene (5.1%), (E)-caryophyllene (4.7%), n-dodecanol (4.5%), caryophyllene oxide (4.2%), bicyclogermacrene ...

BACKGROUND Extracts of Hypericum perforatum (St John's wort) are widely used to treat depression. Evidence for its efficacy has been criticised on methodological grounds. AIMS To update evidence from randomised trials regarding the effectiveness of Hypericum extracts. METHODS We performed a systematic review and meta-analysis of 37 double-blind randomised controlled trials that compared cli...

BACKGROUND AND OBJECTIVE: Pulmonary fibrosis is a chronic interstitial lung disease caused by parenchymal lung damage due to inflammatory factors and fibrosis. Hypericum perforatum contains various flavonoids with antioxidant properties. This study aimed to evaluate protective effects of hydroalcoholic extract of Hypericum against bleomycin-induced pulmonary fibrosis in rats. METHODS: This empi...

Two bioactive xanthones from Hypericum perforatum have been synthesized by direct routes. Benzo[c]xanthone 5 can be prepared from intermediate 4.

background and objective: parkinson's disease (pd) is a neurodegenerative disease with selective damage of mesencephalic dopaminergic neurons. due to the protective, anti-inflammatory, and antioxidant effect of hypericum perforatum (hp), this study was undertaken to assess dose-dependent effect of hp hydroalcoholic extract on motor imbalance following intrastriatal injection of 6-hydroxydo...