Recent studies have suggested that patients with multiple endocrine neoplasia type I (MEN I) may have abnormal serum gastrin secretion in the absence of gastrin producing tumours. G-(gastrin) cell function by three provocation tests in 20 patients with hyperparathyroidism from six MEN I-families were studied: each patient was an obligate carrier of the MEN I-gene. The serum gastrin response to ...

By C. R. DAS GUPTA, M.B. D.TJ\i. AND J. B. CHATTERJEA, M.D. P ERNICIOUS ANEMIA (PA) is essentially a disease of the temperate climate, affecting chiefly the w’hite races. Friedlander’ reviewed the racial incidence of the disease and showed that it is rare in Negroes and comparatively rare in the dark-skinned w’hite races such as Italians and Greeks. It is rather uncommon in Jew-s and is very ra...

BACKGROUND Pathophysiologic actions of Helicobacter pylori colonization on gastric acidity have been hypothesized to modulate the effect of pancreatic carcinogens, through CagA-negative organism strain type, hyperchlorhydria and increased risk of pancreatic cancer, or CagA-positive strain, hypochlorhydria and decreased risk of pancreatic cancer. We aimed to determine H. pylori strain-specific a...

A WRITER, recently reviewing the known facts of the etiology of peptic ulcer, comments on the well-known observation that it is found in that part of the gastrointestinal tract that is directly exposed to gastric juice, and is subjected to the greatest mechanical stress by the passage of the gastric contents.1 Another established fact is the frequent association of ulcer with hyperchlorhydria, ...

Helicobacter pylon (H pyloon) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. Pathophysiologicalpathways bywhichHpylori interacts with acid secretion are still unclear. The effects of H pylon on (14C) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion. Isolated oxyntic glands were stimulated with submax...

Helicobacter pylon (H pyloon) infection is associated with hypo, normal, and hypersecretory disorders of the gastric mucosa. Pathophysiologicalpathways bywhichHpylori interacts with acid secretion are still unclear. The effects of H pylon on (14C) aminopyrine uptake by human parietal cells were examined as an indirect assay for acid secretion. Isolated oxyntic glands were stimulated with submax...

I'HE patient who complains of abdominal pain related to food is often referred for an X-ray examination. Among other things, the barium meal will show the rate of emptying of the stomaclh. In some there will be no delay, but in others there will be retention of barium in the stomach six hours after the meal. A few cases of this nature have been collected, in which fractionial test-meals were al...

Helicobacter pylori status, gastric histology, and 24 hour acidity were studied in 35 gastritis patients, 21 duodenal ulcer patients, and 14 subjects with normal gastric mucosa. Hpylon was identified in 21 of 35 patients with chronic active gastritis and in 19 of 21 duodenal ulcer patients, but in none of those with normal gastric mucosa. Mean scores of activity of gastritis were similar in H p...