نتایج جستجو برای: hynic

تعداد نتایج: 217  

2014
Joerg Kotzerke Robert Punzet Roswitha Runge Sandra Ferl Liane Oehme Gerd Wunderlich Robert Freudenberg

(99m)Tc is the standard radionuclide used for nuclear medicine imaging. In addition to gamma irradiation, (99m)Tc emits low-energy Auger and conversion electrons that deposit their energy within nanometers of the decay site. To study the potential for DNA damage, direct DNA binding is required. Plasmid DNA enables the investigation of the unprotected interactions between molecules and DNA that ...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
Peng Fu Baozhong Shen Changjiu Zhao Guomei Tian

UNLABELLED The mouse double-minute 2 (MDM2) oncogene, amplified or overexpressed in many human cancers, has been suggested to be a novel target for cancer therapy. Visualization of MDM2 expression using radionuclide targeting can provide important diagnostic information in malignant tumors. The overall aim of this study was to evaluate whether liposome-coated (99m)Tc-radiolabeled antisense olig...

2017
Xinchi Hou Bozena Birkenfeld Hanna Piwowarska-Bilska Anna Celler

BACKGROUND Technetium-99m-hydrazinonicotinamide-Tyr3-octreotide (99mTc-HYNIC-TOC) is recognized as a promising radiopharmaceutical for diagnosing neuroendocrine tumors (NETs). However, 99mTc-HYNIC-TOC dosimetry has been investigated only for adults. As pediatric radionuclide therapies become increasingly common, similar dosimetric studies for children are urgently needed. The aim of this study ...

Journal: :Journal of nuclear medicine : official publication, Society of Nuclear Medicine 2010
Damian Wild Andreas Wicki Rosalba Mansi Martin Béhé Boris Keil Peter Bernhardt Gerhard Christofori Peter J Ell Helmut R Mäcke

UNLABELLED Strong overexpression of glucagonlike peptide-1 (GLP-1) receptors in human insulinoma provides an attractive target for imaging. The first clinical trials demonstrated that GLP-1 receptor SPECT/CT using [Lys(40)(Ahx [6-aminohexanoic acid]-DOTA-(111)In)NH(2)]-exendin-4 can localize hardly detectable insulinomas. However, [Lys(40)(Ahx-DOTA-(111)In)NH(2)]-exendin-4 imaging has drawbacks...

Journal: :Clinical nuclear medicine 2012
Dragana P Sobic-Saranovic Smiljana V Pavlovic Vera M Artiko Djordjije Z Saranovic Emilija D Jaksic Dragan Subotic Ljudmila Nagorni-Obradovic Nebojsa Kozarevic Nebojsa Petrovic Isidora T Grozdic Vladimir B Obradovic

PURPOSE The aim of our study was to assess diagnostic accuracy of Tc-99m depreotide and Tc-99m-EDDA/HYNIC-TOC scintigraphy for evaluation of pulmonary lesions that appeared ambiguous on computed tomography (CT). MATERIAL AND METHODS Forty-nine consecutive patients (37 men and 12 women; mean age, 60 ± 11 years) with 60 pulmonary lesions on chest radiography and CT were referred for nuclear ima...

Journal: :asia oceania journal of nuclear medicine and biology 0
ajit s shinto nuclear medicine department, kovai medical center and hospital, india k. kamaleshwaran nuclear medicine department, kovai medical center and hospital, india k vyshak nuclear medicine department, kovai medical center and hospital, india natarajan sudhakar nuclear medicine department, kovai medical center and hospital, india sharmila banerjee isotope applications & radiopharmaceuticals division, bhabha atomic research centre, mumbai, india aruna korde isotope applications & radiopharmaceuticals division, bhabha atomic research centre, mumbai, india

objective(s): the objective of this study was to evaluate the performance and utility of 99mtc hynic-toc planar scintigraphy and spect/ct in the diagnosis, staging and management of gastroenteropancreatic neuroendocrine tumors (gpnets). methods: 22 patients (median age, 46 years) with histologically proven gastroentero-pancreatic nets underwent 99mtc hynic-toc whole body scintigraphy and region...

Journal: :Nuclear medicine and biology 2007
Huub J J M Rennen Peter Laverman Julliëtte E M van Eerd Wim J G Oyen Frans H M Corstens Otto C Boerman

UNLABELLED It was previously shown that the (99m)Tc-labeled hydrazinonicotinamide (HYNIC)-conjugated LTB4 antagonist MB81 visualized infectious foci in rabbits adequately and within a few hours after injection. Here, the bivalent HYNIC-conjugated LTB4 antagonist MB67 (analog of MB81) was fluorinated with (18)F via hydrazone formation and tested in vivo. METHODS MB67 was [(18)F]-fluorinated vi...

Journal: :Scientific reports 2016
Chengyan Dong Sujuan Yang Jiyun Shi Huiyun Zhao Lijun Zhong Zhaofei Liu Bing Jia Fan Wang

We describe herein dual-modality imaging of intraperitoneal colon tumor using an avidin/biotin pretargeting system. A novel dual-modality probe, (99m)Tc-HYNIC-lys(Cy5.5)-PEG4-biotin, was designed, synthesized and characterized. Single-photon emission computed tomography/ computed tomography (SPECT/CT) imaging and near infrared fluorescence (NIRF) imaging were developed using intraperitoneal LS1...

2017
Paulo Henrique Silva Monteiro Thiago Ferreira de Souza Maria Luiza Moretti Mariangela Ribeiro Resende Jair Mengatti Mariana da Cunha Lopes de Lima Allan Oliveira Santos Celso Darío Ramos

Objective To evaluate SPECT/CT with radiolabeled somatostatin analogues (RSAs) in systemic granulomatous infections in comparison with gallium-67 (67Ga) citrate scintigraphy. Materials and Methods We studied 28 patients with active systemic granulomatous infections, including tuberculosis, paracoccidioidomycosis, pneumocystosis, cryptococcosis, aspergillosis, leishmaniasis, infectious vasculi...

Journal: :Molecular imaging 2013
Jiyun Shi Liyang Cui Bing Jia Zhaofei Liu Peng He Chengyan Dong Xiaona Jin Huiyun Zhao Fang Li Fan Wang

There is a critical need to develop diagnostic procedures enabling early detection of tumors while at a curable stage. Technetium 99m (99mTc)-labeled VQ peptide (99mTc-HYNIC-VQ) identified through screening phage display peptide libraries against fresh human colonic adenomas was prepared and evaluated for tumor detection. 99mTc-HYNIC-VQ was prepared by a non-SnCl2 method with more than 99% radi...

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