A single-step method for aniline formation was examined. Using a vanadate catalyst with an iron oxide co-catalyst and hydroxylamine hydrochloride as the amine source, up to 90% yield of obtained high selectivity. Further study showed that overall reaction pseudo-second order in terms concentration. Regioselective H-D exchange experiments suggest C-N bond step occurs via irreversible electrophil...

Synthesis of 3-methoxy acetophenone with substituted benzaldehydes resulted in a number novel chalcones. The chalcones were then treated to cyclization reaction hydroxylamine hydrochloride ethanol enable the synthesis isoxazole derivatives. After purification, structures synthesized compounds identified using TLC, FTIR, 1H NMR, 13C NMR and Mass spectroscopy. carrageenan-induced paw edema method...

In this work, we present an efficient one-pot method for the synthesis of three new azo-isoxazoline derivatives (4a–c) from aromatic aldehydes, hydroxylamine hydrochloride and 4-(allyloxy)azobenzene. Thus, were synthesized via 1,3-dipolar cycloaddition using sodium dichloroisocyanurate (SDIC) as eco-friendly inexpensive oxidizing agent under ultrasound cavitation in water a green solvent. The d...

A new spot test has been developed for the detection of dithiocarbamate fungicides such as mancozeb, propineb and zineb at nkg level in soil and water. The colour formation is based on the decomposition of dithiocarbamate to carbon disulphide which reacts with plumbite i ' alkaline medium to form a brown complex that finally converts to black lead sulphide. The coloured product exists as a brig...

Different novel isoxazolines were synthesized by the cyclization of secondary amino derivatives with pyridazine as a substituted intermediate in presence hydroxylamine hydrochloride. Isoxazoline is an important class nitrogen and oxygen-containing five-membered heterocyclic compounds having great medicinal importance. Many heterocyclic, pharmaceutically active have been using it intermediate. D...

The reaction of indole derivatives with cyanoacetic acid followed by treatment with DMFDMA gave the intermediate indolyl enaminonitriles (3). Further reaction with aminoguanidine yielded 5 ́-cyanomeridianin analogues (4). The same intermediate reacted with pmethoxyphenylhydrazine to give the pyrazolyl derivative (8). Treatment of (2E)-3-dimethylamino-2-(1H-indol-3-yl)-propenoate (3a) with hydrox...

A series of 5-arylisoxazole derivatives were synthesized via the reaction of 3-(dimethyl-amino)-1-arylprop-2-en-1-ones with hydroxylamine hydrochloride in aqueous media without using any catalyst. This method has the advantages of easier work-up, mild reaction conditions, high yields, and an environmentally benign procedure.

A novel and metal-free acrylamides formation between arylpropynes and hydroxylamine hydrochloride through sp(3) C-H and C-C bond cleavage has been achieved with DDQ as an oxidant. The mechanistic study shows that the acrylamides are formed through a three-step tandem sequence, including cross-dehydrogenative-coupling (CDC) reaction, aza-Meyer-Schuster rearrangement and Beckmann rearrangement.

In the present study, an attempt has been made to synthesize 3-methyl-4-arylmethylene isoxazole-5(4H)-one derivatives through sonication of hydroxylamine hydrochloride, ethyl acetoacetate and benzaldehyde derivatives in the presence of imidazole as a novel and effective catalyst in aqueous media. This green reaction under ultrasound irradiation has advantageous compared to conventional...