To investigate the mechanisms underlying motor hyperactivity, we performed intracisternal injection of 6-hydroxydopamine or endocrine disruptors in rats on postnatal day 5. 6-Hydroxydopamine (100 microg, 488 nmol) caused a significant increase in spontaneous motor activities at 4 weeks of age. Gene-expression profiling using a cDNA membrane array revealed alterations in several classes of gene ...

background and objective: parkinson’s disease (pd) is a common neurological disorder due to degeneration of dopaminergic neurons within pars compacta of substantia nigra (snc). with regard to protective effect of malva sylvestris (ms), this study was conducted to evaluate the effect of aquaeous extract of this plant in an experimental model of pd induced by 6-hydroxydopamine (6-ohda). materials...

The relationship between morphological and functional changes in adrenergic nerves and the development of supersensitivity in the rat vas deferens was comparatively investigated after surgical denervation, chemical sympathectomy by 6-hydroxydopamine, daily treatment of animals with reserpine, or local application of colchicine to the hypogastric plexus. The order of ability to produce supersens...

Hydrogen peroxide, superoxide radical, and hydroxyl radical were all formed during the autoxidation of four cytotoxic agents, namely, 6-hydroxydopamine, 6-aminodopamine, 6,7-dihydroxytryptamine, and dialuric acid. Ascorbic acid and 5-hydroxydopamine, two autoxidizable agents of biological interest but without similar cytotoxic actions, were used as negative controls. The results tend to implica...

Monoaminergic innervation of the intermediolateral nucleus of the cat spinal cord was investigated by fluorescence histochemistry and electron microscopy. Large numbers of monoaminergic terminals were labeled by prior administration of the false neurotransmitter 5-hydroxydopamine (5-OHDA). Ultrastructurally, 5-OHDA-labeled terminals fell into three types. Type I, which made up 55% of the labele...

Dopamine and to a much greater extent, 6-hydroxydopamine reduced the growth of the mouse neuroblastoma cell population in vitro but did not induce morphological differentiation. The growth inhibition at a lower drug concentration was primarily due to inhibition of cell multiplication, which was reversible. L-Dopa, norepinephrine, epinephrine, 3,4-dihydroxyphenylacetic acid, or homovanillic acid...