Hydroxychloroquine is used in the therapy of rheumatoid arthritis or lupus erythematosus. Although these diseases are often accompanied by activation of neutrophils, there are still few data relating to the impact of hydroxychloroquine on these cells. We investigated the effect of orally administered hydroxychloroquine on neutrophil oxidative burst in rats with adjuvant arthritis. In human neut...

We present the case of a 75-year-old woman with a medical history of rheumatoid arthritis treated with hydroxychloroquine, who was admitted with acute left-sided heart failure due to a hydroxychloroquine-induced cardiomyopathy as supported by endomyocardial biopsy.

AIMS To assess the characteristics and outcomes of patients with hydroxychloroquine retinopathy and to review the current screening guidelines. METHODS Retrospective chart review of patients diagnosed as having hydroxychloroquine retinopathy at our institution between 2004 and 2008. RESULTS All seven patients were women. While every patient received 400 mg of hydroxychloroquine per day, eve...

Accepted for publication 20 January 1993 Abstract Objectives-In 1985 and 1988 a positive effect of treatment of primary Sj6gren's syndrome with hydroxychloroquine was reported in two small open studies. To investigate further the clinical and laboratory effects of hydroxychloroquine in primary Sjogren's syndrome a two year study was performed. Methods-The design of the study included a prospect...

Accepted for publication 20 January 1993 Abstract Objectives-In 1985 and 1988 a positive effect of treatment of primary Sj6gren's syndrome with hydroxychloroquine was reported in two small open studies. To investigate further the clinical and laboratory effects of hydroxychloroquine in primary Sjogren's syndrome a two year study was performed. Methods-The design of the study included a prospect...

We present a case of a syncopal episode resulting from significant QT interval prolongation in a patient on hydroxychloroquine for the treatment of systemic lupus erythematosus and end stage renal disease. The patient had been treated with hydroxychloroquine for two years prior to presentation. After thorough workup for secondary causes of QT interval prolongation hydroxychloroquine was discont...

For many years chloroquine was used as a prophylactic agent against malaria, and more recently as a mild immunosuppressive. However, due to lengthy treatment periods, adverse effects have become apparent, which included retinopathy. The structurally related hydroxychloroquine is less toxic, thought to be owing to a lower tissue accumulation in melanin rich areas. This study primarily focused on...

Hydroxychloroquine retinopathy is a well-known toxic manifestation of a commonly used systemic medication. The aim of this study was to evaluate the role of automated perimetry in detecting early retinal involvement related to hydroxychloroquine therapy. The study group was made up of 25 patients (21 females and four males, average age 34.5 years) affected by rheumatological diseases treated wi...

Background Hydroxychloroquine and chloroquine may reduce the risk of cancer as they inhibit autophagy, in particular, in people with connective tissue diseases. Methods The hazard ratios of cancers, metastases, and death were assessed in adults with connective tissue diseases prescribed hydroxychloroquine/chloroquine for at least 1 year in comparison with unexposed individuals with the same u...

IMPORTANCE In some patients, hydroxychloroquine ocular toxicity may progress even following cessation of therapy. Any leverage the clinician may use to allow earlier detection may avert significant vision loss. OBSERVATION We report three cases suggesting that bull's eye maculopathy seen on near-infrared reflectance with a confocal scanning laser ophthalmoscope could be an early, objective ma...