The reaction of the tetrahydrobenzo[b]thiophene derivatives 1a,b with benzoylisothiocyanate (2) afforded the thiourea derivatives 3a,b. Cyclization of the latter products gave the annulated products 4a,b. Compounds 3a,b reacted with either hydrazine hydrate (5a) or phenyl hydrazine (5b) afforded compounds 7a-d which underwent cyclization for compounds 7a,c afforded compound 9. On the other hand...

Several studies have indicated that hydrazine produces an amino acid imbalance in experimental animals. The early work of Lewis and Izume (1926) suggested a hydrazine block of amino acid utilization since it impaired the ability of glycine to elevate the blood sugar of hypoglycemic rabbits. More recently, Amenta and Johnston (1963) have investigated the ability of liver slices from hydrazine-tr...

Hydrazine has been determined by its oxidation to nitrogen with a known excess of bromine. Bromine in acidic medium bleaches the dye methyl red. A known excess of bromine when treated with hydrazine is reduced to bromide and the unreacted bromine is determined using methyl red. The molar absorptivity is calculated to be 9.95 x10 L molcm. The method obeys Beer’s law in the range 0-6 μg of hydraz...

BACKGROUND Due to the lower health risks associated with the use of certain categories of smokeless tobacco products (STPs) such as Swedish snus, there is interest in the comparative levels of toxic chemical constituents in different types of STPs. A method has been developed and validated for the analysis of hydrazine in STPs. Seventy four commercial STPs from the US and Sweden, representing 8...

The potential use of hydrazine sulfate was examined for the catalytic reduction of enzymatically generated H2O2 in a biosensor system. The performance of the hydrazine-based sensor was compared with an HRP-based glucose sensor as a model of a biosensor. Hydrazine and HRP were covalently immobilized onto a conducting polymer layer with glucose oxidase. The direct electron transfer reactions of t...

Anaerobic ammonium oxidation is a recent addition to the microbial nitrogen cycle, and its metabolic pathway, including the production and conversion of its intermediate hydrazine, is not well understood. Therefore, the effect of hydroxylamine addition on the hydrazine metabolism of anaerobic ammonium-oxidizing (anammox) bacteria was studied both experimentally and by mathematical modeling. It ...

Prior to World War II, hydrazine was primarily of scientific interest without wide application for practical purposes. However, during World War II the Germans developed techniques for the production of hydrazine hydrate on a tonnage scale for use as rocket and jet fuel, and since then hydrazine and its derivatives have attracted increasing attention from chemists, manufacturers, and the milita...

Electronic structure calculations suggest that hydrazine bisalane (AlH(3)NH(2)NH(2)AlH(3), alhyzal) is a promising compound for chemical hydrogen storage (CHS). Calculations are carried out using the coupled-cluster theory CCSD(T) with the aug-cc-pVTZ basis set. Potential energy surfaces are constructed to probe the formation of, and hydrogen release from, hydrazine bisalane which is initially ...

Many hydrazine derivatives show remarkable biological activities [1]. Hydrazine derivatives are well known among pesticides, drugs, amino acid precursors, and synthetic building blocks for heterocycle synthesis. Several similar compounds were shown to be effective for treatment of tuberculosis, Parkinson’s disease, and hypertension [2]. Also, hydrazine-based peptidomimetics (azapeptides) are fo...

A simple, highly selective and rapid gas chromatography method (packed column with flame ionization detection) has been developed to determine hydrazine and monomethylhydrazine individually and for selective determination of hydrazine in the UH 25 mixture in organic medium. This method is based on the derivatization of hydrazine (at ambient temperature) with 1,1,1-trifluoro-4-(3-thienyl) (CF3 e...