نتایج جستجو برای: hyaluronan binding assay

تعداد نتایج: 616266  

Journal: :Arteriosclerosis, Thrombosis, and Vascular Biology 2021

Objective: The dominant driver of arteriogenesis is elevated shear stress sensed by the endothelial glycocalyx thereby promoting arterial outward remodeling. Hyaluronan, a critical component glycocalyx, synthesized 3 HAS isoenzymes (hyaluronan synthases 1-3) at plasma membrane. Considering further importance HAS3 for smooth muscle cell and immune functions we aimed to evaluate its role in colla...

Journal: :Trends in Biotechnology 2021

The extracellular matrix is composed of hyaluronan different molecular weights that play roles in cellular proliferation, migration, and differentiation. dysregulated accumulation alters the mechanical biochemical properties it associated with several pathological states. Biomaterials can be engineered using native backbone or chemically modified to target cells via specific receptors, such as ...

Journal: :Pharmacological reports : PR 2013
Michał S Karbownik Jerzy Z Nowak

The understanding of the role of hyaluronan in physiology and various pathological conditions has changed since the complex nature of its synthesis, degradation and interactions with diverse binding proteins was revealed. Initially perceived only as an inert component of connective tissue, it is now known to be involved in multiple signaling pathways, including those involved in cancer pathogen...

2017
Lukas Kessler Sandra Gehrke Marc Winnefeld Birgit Huber Eva Hoch Torsten Walter Ralf Wyrwa Matthias Schnabelrauch Malte Schmidt Maximilian Kückelhaus Marcus Lehnhardt Tobias Hirsch Frank Jacobsen

In vitro-generated soft tissue could provide alternate therapies for soft tissue defects. The aim of this study was to evaluate methacrylated gelatin/hyaluronan as scaffolds for soft tissue engineering and their interaction with human adipose-derived stem cells (hASCs). ASCs were incorporated into methacrylated gelatin/hyaluronan hydrogels. The gels were photocrosslinked with a lithium phenyl-2...

Journal: :American journal of respiratory cell and molecular biology 1997
P Teder P Heldin

Hyaluronan, a linear polysaccharide, is accumulated in lung interstitium during different pathological conditions, causing interstitial edema and thereby impaired lung function. We investigated the mechanism of local hyaluronan turnover during the early phase of bleomycin-induced fibrotic lung injury in rats. The binding of [3H]hyaluronan to alveolar macrophages (AM) established from bleomycin-...

2014
Justine J. Roberts Robert M. Elder Alexander J. Neumann Arthi Jayaraman Stephanie J. Bryant

This study investigates the incorporation of hyaluronan (HA) binding peptides into poly(ethylene glycol) (PEG) hydrogels as a mechanism to bind and retain hyaluronan for applications in tissue engineering. The specificity of the peptide sequence (native RYPISRPRKRC vs non-native RPSRPRIRYKC), the role of basic amino acids, and specificity to hyaluronan over other GAGs in contributing to the pep...

Journal: :iranian journal of pharmaceutical research 0
fatemeh ahmadi department of radiopharmacy, school of pharmacy, tehran university of medical sciences sara dabirian department of pharmaceutical chemistry, school of pharmacy, shahid behesti university of medical sciences mehrdad faizi department of pharmacology and toxicology, school of pharmacy, shahid beheshti university of medical sciences sayyed abbas tabatabai department of pharmaceutical chemistry, school of pharmacy, shahid behesti university of medical sciences davood beiki research center for nuclear medicine, tehran university of medical sciences soraya shahhosseini department of pharmaceutical chemistry, school of pharmacy, shahid beheshti university of medical sciences

to obtain drugs which are more selective at benzodiazepine (bzd) receptors, design and synthesis of functionally selective ligands for bzd receptors is the current strategy of our pharmaceutical chemistry department. the affinity of newly synthesized ligands is assessed by radioligand receptor binding assays. based on our previous studies, 2-phenyl-5-oxo-7-methyl-1,3,4-oxadiazolo[a,2,3]-pyrimid...

Journal: :BMC Musculoskeletal Disorders 2004
Charles W Prince

BACKGROUND Hyaluronan, an unsulfated glycosaminoglycan, while being closely linked to osteoclast function several years ago, has received little attention lately. Given recent new knowledge of hyaluronan's possible cell binding abilities, it is important to re-examine the role of this polysaccharide in bone homeostasis. DISCUSSION Previously published data demonstrating a linkage between indu...

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