Hydrogen exchange technology provides a uniquely powerful instrument for measuring protein structural and biophysical properties, quantitatively and in a nonperturbing way, and determining how these properties are implemented to produce protein function. A developing hydrogen exchange-mass spectrometry method (HX MS) is able to analyze large biologically important protein systems while requirin...

Hemopexin (Hx) is a plasma glycoprotein mainly expressed in liver and, less abundantly, in the central and peripheral nervous systems. Hx has a high binding affinity with heme and is considered to be a major transport vehicle of heme into the liver, thus preventing both heme-catalyzed oxidative damage and heme-bound iron loss. To determine the physiologic relevance of heme-Hx complex formation,...

We have conducted studies to determine the potential of exercise to benefit the injured spinal cord using neurotrophins. Adult rats were randomly assigned to one of three groups: (1) intact control (Con); (2) sedentary, hemisected at a mid-thoracic level (Sed-Hx), or (3) exercised, hemisected (Ex-Hx). One week after surgery, the Ex-Hx rats were exposed to voluntary running wheels for 3, 7, or 2...

BACKGROUND Although laparoscopic liver resection has developed rapidly and gained widespread acceptance for the treatment of benign liver diseases and hepatocellular carcinoma with a small tumor size, its usefulness for the treatment of large tumors is less clear, due to concerns about compromising oncological principles and patient safety. The purpose of this study was to explore the safety an...

17 Let L p d A via k-tt-condition f(x) = h; y 1 ;. . .; y k i, that is, for each x 2 6 3 , x 2 L if and only if Ass(f(x)) \ A 6 = ;. Without loss of generality, assume that the length of each y 2 Ass(f(x)) is exactly q(jxj), q 2 I Pol. Let A 2 9 1 SP 1 K. Then, there exist a set B 2 SP 1 K and a polynomial p such that for every y 2 6 3 , y 2 A if and only if there exists a string z, jzj = p(jyj...

6. [This is simply an adapted proof of Theorem 2.4.2.] First observe that, the map φ(g) [for a fixed g ∈ G] is well defined: Hx = Hy iff xy−1 ∈ H iff xg−1gy−1 ∈ H iff (xg−1)(yg(−1)−1 ∈ H iff Hxg−1 = Hyg−1 iff φ(g)(Hx) = φ(g)(Hy). Note also, that since we have equivalencies in all steps above, we also have proved that φ(g) is one-to-one. Also, for a fixed g ∈ G, the map φ(g) : Hx 7→ Hxg is indee...

The population genetic history of a 10.1-kbp noncoding region of the human X chromosome was studied using the males of the HGDP-CEPH Human Genome Diversity Panel (672 individuals from 52 populations). The geographic distribution of patterns of variation was roughly consistent with previous studies, with the major exception that 1 highly divergent haplotype (haplotype X, hX) was observed at low ...

Acute hypoxia (9.5% O2) increased the heart rate (HR) in hypoxia (12% O2 for 2 months)-acclimated (HX) rats, while it decreased HR in unacclimated (CT) rats. After treatment with propranolol, acute hypoxia decreased HR to the same extent in CT and HX rats. After treatment with atropine, acute hypoxia increased HR in HX rats but not in CT rats. The hypoxia-induced tachycardia in HX rats may be m...

The current study tested the emotional reactivity of smokers with and without histories of major depression (MDD Hx) and trauma exposure (TE). Four counterbalanced conditions nested negative (e.g., dysphoric) or neutral mood inductions with in vivo versus control smoking paraphernalia cues (Neutral+Control; Neutral+Cigarette; Neg+Control; Neg+Cigarette). Mixed model analysis of covariance (ANCO...