نتایج جستجو برای: human umbilical vascular endothelial cell huvec

تعداد نتایج: 3111777  

Journal: :Infection and immunity 2000
A J Vriesema H Beekhuizen M Hamdi A Soufan A Lammers B Willekens O Bakker A G Welten M H Veltrop J S van De Gevel J Dankert S A Zaat

Staphylococcus aureus is isolated from a substantial number of patients with infective endocarditis who are not known to have predisposing heart abnormalities. It has been suggested that the infection is initiated by the direct binding of S. aureus to human vascular endothelium. To determine the mutual response of the endothelial cells and the bacteria, we studied the interaction between S. aur...

Journal: :Food Science and Technology 2021

The aim of this study was to provide a scientific basis for anti-arthritic and anticancer activities by inhibiting cellular adhesion molecule (CAM) expression ingestion Aralia elata (Miq.) Seem (A. elata), which is used in traditional medicine East Asia. A. extract inhibited the between monocytic THP-1 human umbilical vein endothelial cells (HUVEC) monolayers, respectively, compared TNF-α-treat...

Journal: :The Journal of endocrinology 2000
A M Corbacho Y Macotela G Nava L Torner Z Dueñas G Noris M A Morales G Martínez De La Escalera C Clapp

Members of the prolactin (PRL) hormonal family have direct effects on endothelial cell proliferation, migration and tube formation. Moreover, isoforms of PRL may function as autocrine regulators of endothelial cells. Bovine brain capillary endothelial cells (BBCEC) express the PRL gene, while anti-PRL antibodies inhibit BBCEC proliferation. Here, we show the expression of the PRL gene into vari...

Journal: :Arteriosclerosis, thrombosis, and vascular biology 2013
Martin S Kluger Paul R Clark George Tellides Volker Gerke Jordan S Pober

OBJECTIVE To assess the role claudin-5, an endothelial cell (EC) tight junction protein, plays in establishing basal permeability levels in humans by comparing claudin-5 expression levels in situ and analyzing junctional organization and function in 2 widely used models of cultured ECs, namely human dermal microvascular (HDM)ECs and human umbilical vein (HUV)ECs. METHODS AND RESULTS By immuno...

2013
Gi Dae Kim Oug Jae Cheong Song Yi Bae Jongheon Shin Sang Kook Lee

Hamacanthins, bis (indole) alkaloids, are found in a few marine sponges, including Spongosorites sp. Hamacanthins have been shown to possess cytotoxic, antibacterial and antifungal activities. However, the precise mechanism for the biological activities of hamacanthins has not yet been elucidated. In the present study, the anti-angiogenic effects of 6"-debromohamacanthin A (DBHA), an active com...

2014
Jian-Hua Wang Lin-Jing Yuan Zhi-Min Zhong Zhe-Sheng Wen Jian-Ming Deng Rong-Xin Liang Min Zheng

The selection of vascular grafts for coronary artery bypass surgery is crucial for a positive outcome. This study aimed to establish a novel line of vascular endothelial cells with a potent anticoagulant effect. A lentiviral vector was used to stably transfect human umbilical vein endothelial cells (HUVECs) with PGI2S alone (HUVEC-PGI2S) or both PGI2S and tPA (HUVEC-PGI2S-tPA). Both HUVEC-PGI2S...

Journal: :Oncology reports 2007
Mila Donker Wouter R Van Furth Sacha Mulder-Van Der Kracht Koos E Hovinga Joost J C Verhoeff Lukas J A Stalpers Chris van Bree

Glioblastoma multiforme (GBM) is a radioresistant tumor. Tumor neoangiogenesis is an important mechanism for tumor sustenance. Angiogenesis is primarily mediated by vascular endothelial growth factor (VEGF), and earlier studies have suggested that VEGF protects human umbilical vein endothelial cells (HUVECs) against high doses of radiation. We tried to extend these findings to other endothelial...

2014
Shuhei Yamamoto Michael Masakuni Hotta Mina Okochi Hiroyuki Honda

In vitro three dimensional (3D) cancer models were developed to observe the invasive capacity of melanoma cell spheroids co-cultured with the vascular-formed endothelial cell network. An array-like multicellular pattern of mouse melanoma cell line B16F1 was developed by magnetic cell labeling using a pin-holder device for allocation of magnetic force. When the B16F1 patterned together with a va...

2014
Qun Shu Wenjiao Li Haichuan Li Gang Sun

Anti-angiogenesis treatment has been a promising new form of cancer therapy. Endothelial cells are critical for vascular homeostasis and play important roles in angiogenesis, vascular and tissue remodeling. Vasostatin, the 180 amino acid N-terminal fragment of the calreticulin protein, is reported to be a potent endogenous inhibitor of angiogenesis, suppressing tumor growth. However, the mechan...

2005
Jeanna Jacobi Shifra Sela Hector I. Cohen Judith Chezar Batya Kristal

Peripheral polymorphonuclear leukocytes (PMNL) in hemodialysis patients (HD) are primed, continually releasing and exposing the vascular endothelium to soluble factors such as reactive oxygen species (ROS) and inflammatory mediators. To mimic the close proximity between PMNL and the endothelial monolayer, and to monitor and characterize the influence of soluble mediators released from PMNL, we ...

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