Chalkley, S. R., and Tanner, J. M. (1971). Archives of Disease in Childhood, 46, 160. The incidence and effects on growth of antibodies to human growth hormone. Antibodies to human growth hormone (HGH) have been measured by radioimmunoassay on one or more occasions in 98 children with short stature treated with HGH, and in 51 other children. Positive antibody binding reactions occurred in nearl...

The effects of oxandrolone or biosynthetic human growth hormone (r-hGH) on the growth of 26 boys with constitutional delay of growth and puberty were studied. Both regimens increased growth rate twofold, oxandrolone to a greater extent than r-hGH. We conclude that oxandrolone is a more effective method of increasing growth rate in such children.

Primary somatomedin deficiency: case report. A child presenting with the clinical features of hyposomatotropism but with high immunoreactive plasma growth hormone is described. During short-term administration of human growth hormone (HGH) his response with regard to fasting blood-glucose and free fatty acids, plasma-somatomedin, urinary excretion of calcium, nitrogen, and hydroxyproline was mi...

Paediatr Suppl 1999;88:200–8. 21. Wajnrajch MP, Gertner JM, Mullis PE, Deladoëy J, Cogan JD, Lekhakula S, et al. ARGHIS is a new mutational “hot-spot” in the growth hormone (GH) gene causing isolated GH deficiency type II. J Endocr Genet 2001;1:125– 35. 22. Wada M, Uchida H, Ikeda M, Tsunekawa B, Naito N, Banba S, et al. The 20-kilodalton (kDA) human growth hormone (hGH) differs from the 22-kDA...

Introduction The parenteral administration of human growth hormone (HGH) has become an intervention of great significance in anti-aging medicine. There is now frenetic interest in using reliable G H secretagogues i n the form of peptides, such as GHRP-2. Although age-related sarcopenia is related to HGH deficiency, the use of HGH for the building of "lean body mass" has been questioned, especia...

Daily injection of 8IU of methionyl human growth hormone (met-hGH), produced by recombinant DNA technology, was performed in healthy young volunteers. Daily injections for four days did not cause any significant change in the results of physical examination, electrocardiogram, blood count or urinalysis. Non-esterified fatty acid levels increased significantly at 4 hours after the first injectio...

Triiodothyronine (T3) induces the transcription of the human chorionic somatomammotropin (hCS) promoter transfected into rat pituitary (GC) cells, but does not stimulate the homologous human growth hormone (hGH) promoter. As demonstrated by forward and reverse mutagenesis, this differential T3 responsiveness is due to subtle structural differences in a T3 response element located between nucleo...

Nonviral gene transfer was investigated as a potential treatment of growth hormone deficiency (GHD) using hypophysectomized mice as a model. After a single hydrodynamic administration of naked plasmid DNA containing the human growth hormone (hGH) gene controlled by an ubiquitin promoter, sustained elevation of circulating hGH was observed the entire observation period (68 days), with a concomit...

In the radioreceptor assay for growth hormone (RRA-GH) using [125I]iodo-hGH, hGH and human liver membrane particulate fractions as tracer, hormone standard and receptors, respectively, ovine placental lactogen (oPL) is capable of inhibiting the binding of [125I]iodo-hGH in a parallel manner with hGH and in equipotency. Similarly, in the RRA-GH by employing [125I]iodo-oPL, oPL and human liver me...

Isolated rat hepatocytes accumulate a slowly dissociable human growth hormone (hGH) binding fraction with incubation time. Slowly dissociable [125I]hGH is receptor bound, intact and immunocompetent. Fifty-six percent of the bound hormone was slowly dissociable within 3 min of the initiation of hGH-hepatocyte incubation. Subsequently, the proportion of slowly dissociable [125I]hGH increased at t...