objective: human cytomegalovirus (hcmv) is a beta-herpesvirus that causes persistent infection in humans, as well as severe disease in fetuses and immunocompromised individuals. although hcmv is not currently causally implicated in human cancer, emerging evidence suggests that hcmv infection may be specifically associated with malignancies such as gliomas. gliomas are one of the most common bra...

Rhesus cytomegalovirus (RhCMV) is an emerging model for human cytomegalovirus (HCMV) pathogenesis that facilitates experimental CMV infection of a natural primate host closely related to humans. We have generated a library of RhCMV mutants with lesions in genes whose HCMV orthologues have been characterized as nonessential for replication in human fibroblasts, and we characterized their replica...

Human cytomegalovirus (HCMV) is a herpesvirus that is prevalent in the human population. HCMV has recently been implicated in different cancer forms where it may provide mechanisms for oncogenic transformation, oncomodulation and tumour cell immune evasion. Moreover, antiviral treatment against HCMV has been shown to inhibit tumour growth in preclinical models. Here we describe the possible inv...

objective: assessment of subgingival human cytomegalovirus (hcmv) and epstein barr virus (ebv-1) in subjects with aggressive periodontitis. materials and methods: samples were obtained from plaques formed in subgingival regions of 26 aggressive periodontitis patients. all specimens were submitted to polymerase chain reaction in order to detect hcmv and ebv-1. results: hcmv and ebv-1 were observ...

Reactivation and shedding of human cytomegalovirus (HCMV) in breast milk during lactation is highly frequent HCMV-seropositive mothers. This represents a key transmission route for postnatal HCMV infection can lead to severe disease preterm neonates. Little known about strain composition or longitudinal intrahost viral population dynamics from immunocompetent women. We performed HCMV-specific t...

The severe shortage of human organs for transplantation is the driving force behind xenotransplant research. Nonhuman primates, particularly baboons, are potential sources of organs and tissues. Human cytomegalovirus (HCMV) is the most common donor-associated infection after allotransplantation. Baboon cytomegalovirus (BCMV) is endemic in baboon populations and therefore is a potential cause of...

The effect of abrogating the interferon (IFN) response on human cytomegalovirus (HCMV) replication was investigated using primary human cells engineered to block either the production of or the response to type I IFNs. In IFN-deficient cells, HCMV produced larger plaques and spread and replicated more rapidly than in parental cells. These cells demonstrate the vital role of IFNs in controlling ...

background and aims: primary infections of rubella and human cytomegalovirus (hcmv) can lead to severe complications in pregnancy. the screening of rubella and hcmv in pregnant women is not routinely carried out in iran. this cross sectional study aimed to investigate the seroprevalence of hcmv and rubella infections in neonates with and without congenital defects. materials and methods: this s...

conclusions in this study, high prevalence of 91.7% hcmv gb1 genotype was predominant among hcmv-positive uc patients, which suggests that there might be an association between hcmv gb genotype 1 and uc disease. results among 98 patients with uc, only 12 (12.2%) patients were positive for hcmv genome, while the hcmv genome was not detected in any of the controls. (p = 0.002). the distribution o...