Emergence of drug resistance and adverse effects often affect the efficacy nucleoside analogues in therapy Herpes simplex type 1 (HSV-1) 2 (HSV-2) infections. Host-targeting antivirals could therefore be considered as an alternative or complementary strategy management HSV To contribute to this advancement, here we report on ability a new generation inhibitor key cellular enzyme de novo pyrimid...

Herpes Simplex Virus type 1 (HSV-1) is usually the cause of oral infection. This infection oftenprecedes development this chronic anemia, and it reasonable that blood in circulation through virusinfectedtissue becomes contaminated with virus particles on red cell surface. These virus-contaminated redblood cells may stimulate reticuloendothelial system to produce antibodies destroy andlead anemi...

purpose: the main purpose of this study was to evaluate the prevalence of herpes simplex virus 1 and 2 (hsv-1 and hsv-2), varicella-zoster virus and adenovirus associated with conjunctivitis in swab samples of patients who referred to eye specialist hospitals in tehran. methods: in this cross-sectional study, swab samples from patients with acute conjunctivitis during the first sixth months of ...

Herpes simplex virus types 1 (HSV-1) and 2 (HSV-2) are members of the Herpesviridae family. About 40% to 80% of the world populations are infected with HSV and its prevalence is high in Iran. The high prevalence of this virus in the community and the ability of the virus in causing fatal diseases among immunocompromised patients, have encouraged studies to be performed on HSV and suitable cell ...

Background and Aims: Sexually transmitted infections (STIs) are of major concern to clinicians and researchers in the field of reproductive medicine. Many STI pathogens cause incurable and often fatal diseases, and have been transmitted through insemination procedures. The role of herpes simplex virus in male infertility has been investigated using the sensitive methods. The aim of this study w...

Background Researching people with herpes simplex virus (HSV) is challenging because of poor data quality, low user engagement, and concerns around stigma anonymity. Objective This project aimed to improve collection for a real-world HSV registry by identifying predictors infection selecting limited number relevant questions ask new users determine their level risk. Methods The US National Heal...

herpes simplex virus type 1 (hsv-1) is a member of the herpesviridae family that causes herpetic disease in human. during the last 25-30 years, many investigations have been conducted on pathogenesis and molecular biology of this virus in several countries. in iran hsv-1 has been isolated from patients and detected using immunological techniques. in this study, we investigated the molecular asp...

Background: Oncolytic herpes simplex virus (oHSV)-based vectors lacking γ34.5 gene, are considered as ideal templates to construct efficient vectors for (targeted) cancer gene therapy. Herein, we reported the construction of three single/dually-flourescence labeled and γ34.5-deleted, recombinant HSV-1 vectors for rapid generation and easy selection/isolation of different HSV-Based v...