The expression of human squalene synthase (HSS) gene is transcriptionally regulated in HepG-2 cells, up to 10-fold, by variations in cellular cholesterol homeostasis. An earlier deletion analysis of the 5'-flanking region of the HSS gene demonstrated that most of the HSS promoter activity is detected within a 69-base pair sequence located between nucleotides -131 and -200. ADD1/SREBP-1c, a rat ...

Stream biofilms are exposed to dynamic conditions of flow velocity and organic carbon availability. Thus, the aim of this study was to investigate the response of biofilms formed with and without humic substances (HSs) to an increase in flow velocity (0.04-0.10 ms(-1)) and HSs concentration (9.7+/-1.0 to 19.8+/-0.4 mgL(-1) C). The highest amount of biofilm, measured as volatile suspended solids...

Despite fruitful studies on knowledge flow and interdisciplinarity, there are few investigations on knowledge flow in humanities and social sciences (HSS) and how knowledge from science and technology diffuses to HSS sub-disciplines. Based on Chinese and English articles in HSS, this study explored knowledge flow in China’s HSS with an analysis of Chinese and English publications from 1998 to 2...

This paper presents a hybrid metaheuristic algorithm which is Harmony-Scatter Search (HSS). The HSS provides Scatter Search (SS) with random exploration for search space of problem and more of diversity and intensification for promising solutions. The SS and HSS have been tested on Traveling Salesman Problem. A computational experiment with benchmark instances is reported. The results demonstra...

BACKGROUND & OBJECTIVES HIV sentinel surveillance (HSS) among antenatal clinic (ANC) attendees is used to monitor HIV trends in general population. Recently, information on HIV infection has also become available from prevention of parent-to-child transmission (PPTCT) programmes. Systematic appraisal of routinely collected programme data is needed for choosing a scientific, cost-effective, and ...

AIM To test the safety and effectiveness of hypertonic saline solution (HSS + F) as a strategy for weight loss and prevention of further deterioration of renal function. METHODS Patients admitted with acute decompensated heart failure (ADHF) who received HSS + F were included in the study. After a period of a standard ADHF treatment, our patients received an intravenous infusion of furosemide...

Homospermidine synthase (HSS), the first pathway-specific enzyme of pyrrolizidine alkaloid biosynthesis, is known to have its origin in the duplication of a gene encoding deoxyhypusine synthase. To study the processes that followed this gene duplication event and gave rise to HSS, we identified sequences encoding HSS and deoxyhypusine synthase from various species of the Convolvulaceae. We show...

Hierarchically semiseparable (HSS) matrix techniques are emerging in constructing superfast direct solvers for both dense and sparse linear systems. Here, we develop a set of novel parallel algorithms for key HSS operations that are used for solving large linear systems. These are parallel rank-revealing QR factorization, HSS constructions with hierarchical compression, ULV HSS factorization, a...

We present some superfast (O((m + n) log(m + n)) complexity) and stable structured direct solvers for m× n Toeplitz least squares problems. Based on the displacement equation, a Toeplitz matrix T is first transformed into a Cauchy-like matrix C, which can be shown to have small off-diagonal numerical ranks when the diagonal blocks are rectangular. We generalize standard hierarchically semisepar...

The mammalian beta-globin locus is a multigenic, developmentally regulated, tissue-specific locus from which gene expression is regulated by a distal regulatory region, the locus control region (LCR). The functional mechanism by which the beta-globin LCR stimulates transcription of the linked beta-like globin genes remains unknown. The LCR is composed of a series of 5 DNaseI hypersensitive site...