Eradication and elimination are increasingly a part of the global health agenda. Once control measures have driven infection to low levels, the ecology of disease may change posing challenges for eradication efforts. These challenges vary from identifying pockets of susceptibles, improving monitoring during and after the endgame, to quantifying the economics of disease eradication versus sustai...

Theoretical results show that the measles 'pulse' vaccination strategy can be distinguished from the conventional strategies in leading to disease eradication at relatively low values of vaccination. Using the SIR epidemic model we showed that under a planned pulse vaccination regime the system converges to a stable solution with the number of infectious individuals equal to zero. We showed tha...

A recurring theme in the epidemiological literature on disease eradication is that each pathogen occupies an ecological niche, and eradication of one pathogen leaves a vacant niche that favours the emergence of new pathogens to replace it. However, eminent figures have rejected this view unequivocally, stating that there is no basis to fear pathogen replacement and even that pathogen niches do ...

malaria has always been regarded as one of the most important health problems with which iran is faced. most parts of the country, especially densely populated areas, were known as malarious areas. records of 1947 show that 25% of cases referred to health centers and dispensaries of the ministry of health were due to malaria in khuzestan and caspian sea areas. the mortality rate of malaria in t...

helicobacter pylori is an important human pathogen and a gram-negative, spiral shaped and microaerophilic bacteria with persistence colonization in gastric mucosa, causes gastroduodenal inflammation and destruction, resulting in diseases such as duodenal ulcer disease, gastric ulcer disease. when h.pylori discovered by warren and marshall, effective therapy developed for this infection and resu...

background: furazolidone has been used as an alternative for clarithromycin or metronidazole in helicobacterpylori ( h . pylori ) eradication regimens.  in iran, 14-day furazolidone-containing quadruple regimens have shown promising eradication rates, but short-course, low dose therapies are always attractive. therefore, we designed a study to compare the efficacy of two 10-day triple regimens ...

Helicobacter pylori (H. Pylori) infection is currently recognized as the major cause of chronic active gastritis, peptic ulcer disease and mucosa associated lymphoid tissue (MALT) lymphoma and carcinoma of the stomach. Eradication of the infection will prevent the recurrence of the majority of such diseases. Different combined treatments have been tried in Iran for eradication of H. Pylori, but...

furazolidone (fzd), a nitrofuran derivative, is an antibacterial agent in use by the medical and veterinary fields. the chinese have utilized fzd to relieve stomach pain, 5 years before the discovery of helicobacter pylori. this drug is currently a part of helicobacter pylori's eradication regimen. however, some carcinogenic and toxic adverse effects associated with fzd have been observed in an...

background h. pylori infection in the stomach was the first major cause of gastritis and peptic ulcer disease and gastric adenocarcinoma and lymphoma (malt). evaluation of the infection eradication is important. h. pylori infection was associated with gastric glands dysfunction such as increased serum gastrin and increased secretion of pepsinogen. in recent years the measurement of serum gastri...