A hydroxypropyl methylcellulose (HPMC K4M, HPMC K15M, and HPMC K100M) matrix tablet containing Indomethacin along with mannitol was formulated as a function of HPMC viscosity, and was compared with the commercial products. The release characteristics of the matrix tablet were investigated in the intestinal fluid, 6.8 pH phosphate buffer for 12 hours. The formulated products and two marketed pro...

Various methods are available to formulate water soluble drugs into sustained release dosage forms by retarding the dissolution rate. One of the methods used to control drug release and thereby prolong therapeutic activity is to use hydrophilic and lipophilic polymers. In this study, the effects of various polymers such as hydroxypropyl methylcellulose (HPMC), ethylcellulose (EC) and sodium car...

In the present work, Bilayered matrix type tablet were prepared by direct and wet granulation technique, in which immediate release layer ( compression) contains Nebivolol extended (by granulation) Nateglinide. All developed bilayer tablets evaluated for weight variation, friability, thickness hardness. The percent deviation from average weight, hardness was found to be within prescribed offici...

Gastroretentive tablets of propranolol hydrochloride were developed by direct compression method using citric acid and sodium bicarbonate as the effervescent base. Hydroxypropyl methylcellulose; HPMC K15M was used to prepare the floating tablets to retard the drug release for 12h in stomach. Na-carboxymethyl cellulose (NaCMC) or carbopol 934P was added to alter the drug release profile or the d...

In the present study, several combinations of different grades of hydroxy propyl methyl cellulose (HPMC) such as HPMC-K4M, HPMC-K15M, HPMC-K100M as hydrophilic polymers and hydrophobic polymer like ethyl cellulose(EC) are used to prepare the matrix tablets that resulted in desired and controlled drug release profile. Hydrophobic polymers provide several advantages including good stability at va...

Objective: The Losartan potassium mucoadhesive buccal tablet were prepared using mucoadhesive polymers such as Carbopol 940P, pectin, sodium CMC, Sodium alginate, HPMC K4M, HPMC K15M and HPMC K100M in alone and in combination as release retarding agent to prolong the drug release and to avoid first pass metabolism. Methods: The mucoadhesive buccal tablets were prepared by direct compression met...

The overall aim of the present study was to widen our knowledge about the biopharmaceutical behaviour of novel hydroxypropyl methylcellulose (HPMC)-based two-piece capsules by comparing them with the classic hard gelatine capsules. Firstly, the tendency of the HPMC capsules to stick to isolated porcine oesophageal preparation was evaluated. The force needed to detach the HPMC capsules from the ...

Silver ion has been used for centuries to prevent and treat a variety of diseases and infections. In recent years, extensive studies have been undertaken on the use of antimicrobial properties of silver, incorporated within medical devices. The aim of this study was to prepare a formulation containing silver ion, which could be applied for wound dressing. The purity of nanosilver was measured b...

Objective: The aim of present investigation was to develop HBS system (sustained release) for Verapamil HCl used for the treatment of hypertension. The drug delivery system was designed to retain the system in stomach so that increase in absorption of drug and decrease in dosing interval. Methodology: Single unit capsules were filled with weighed mixture of Verapamil HCl and polymers such as HP...