A solid biopolymer electrolytes (BEs) based on hydroxypropyl methylcellulose (HPMC) doped with different concentrations of ceric ammonium nitrate (NH4)2Ce(NO3)6 (CAN) were prepared by solution cast method. Different techniques has been employed to investigate the effects of structural, thermal and ionic conductivity behavior of these polymer electrolyte films upon gamma irradiation with differe...

BACKGROUND AND THE PURPOSE OF THE STUDY Sertraline hydrochloride is a selective serotonin reuptake inhibitor principally used in the treatment of major depressive disorder. To maintain the therapeutic plasma drug concentration of the drug for prolonged period, the transdermal drug delivery has been chosen as an alternative route of drug delivery. The pharmacokinetic properties of sertraline hyd...

Purpose: To formulate matrix type sustained-release (SR) tablets of tizanidine hydrochloride (TH) for prolonged drug release and improvement in motor activity after spinal injuries. Methods: Matrix tablets were prepared by the wet granulation method using four polymers (hydroxyl propyl methyl cellulose [HPMC] K 100, ethyl cellulose [EC], guar gum, and polyvinylpyrrolidone (PVP K30) and characte...

The objective of the present study was to develop sustained release oral matrix tablets of anti epileptic drug levetiracetam. The sustained release matrix tablets of levetiracetam were prepared using hydrophilic matrix hydroxypropyl methylcellulose (HPMC) as a release retarding polymer by wet granulation method. Prior to compression, FTIR studies were performed to understand the compatibility b...

The objective of this study was to develop and optimize the gliclazide extended-release formulations by using simultaneously combination of two hydrophilic polymers: HPMC K 15M and sodium alginate as retardant. D-Optimal mixture design was employed to evaluate the effect of HPMC (X(1)), lactose (X(2)), and sodium alginate (X(3)) concentrations on the release rate of gliclazide from the matrices...

BACKGROUND Chronic peritoneal dialysis (PD) is associated with peritoneal calcification. Studies in vascular tissue suggest that ectopic calcification is not merely a passive but a regulated process resembling bone mineralization. We investigated whether peritoneal calcification is controlled by matrix Gla protein (MGP) secreted by peritoneal mesothelial cells. METHODS Human primary mesotheli...

Purpose: To comparatively evaluate the effect of two hydroxylpropyl methylcellulose (HPMC) molecular weight grades (K4M and K15M) on drug release from diclofenac sodium matrix tablets. Methods: Tablets containing diclofenac sodium were prepared by direct compression method at various drug/HPMC ratios and evaluated in vitro for their water uptake, erosion and dissolution characteristics over a p...

INTRODUCTION The percolation theory studies the critical points or percolation thresholds of the system, where one component of the system undergoes a geometrical phase transition, starting to connect the whole system.The application of this theory to study the release rate of hydrophilic matrices allows to explain the changes in release kinetics of swellable matrix type system and results in a...

The influence of polyvinylpyrrolidone (PVP), a commonly used binder and adhesive, on the aggregation of spheroids coated with hydroxypropylmethylcellulose (HPMC) was studied. The aggregation propensities of spheroids coated by HPMC alone and by HPMC with polyethylene glycol (PEG) were compared with those coated by HPMC with PVP and the viscosity of the coating solutions determined. The coating ...

Hydroxypropylmethylcellulose (HPMC) and methylcellulose (MC) are modified cellulose dietary fibers that generate viscous solutions in the gastrointestinal (GI) tract. This study assessed the effects of high viscosity (HV) HPMC, ultra-HV (UHV) HPMC, and medium viscosity MC on postprandial glucose and insulin responses in overweight and obese men and women (n = 50). After overnight fasts, subject...