This study was performed to demonstrate accumulation of the photosensitizer hematoporphyrin derivative (HPD) in atherosclerosis and to determine whether intimal hyperplasia, the main cause of restenosis after angioplasty, can be inhibited by photodynamic therapy (PDT). Forty Japanese White rabbits were subjected to balloon endothelial injury in the common iliac artery. Five groups of rabbits, i...

A variable-phase-shifter (VPS) architecture with hybrid precoding for mixture use of phase shifters and switches, is proposed millimeter wave massive multiple-input multiple-output communications. For the VPS architecture, a design (HPD) scheme, called VPS-HPD, to optimize phases according channel state information by alternately optimizing analog precoder digital precoder. To reduce computatio...

AIM To elucidate the mechanism of the potentiating influence of heating associated with photoirradiation on the antitumor efficiency of photodynamic therapy (PDT) with hematoporphyrin derivative (HPD). METHODS The study was carried out on Ehrlich ascites carcinoma (EAC) cells, which were loaded with HPD in a serum-free medium and then irradiated with red light (lambda max=630 nm) at various t...

Hematoporphyrin derivative (HPD) is a potent photosensitizer which localizes preferentially in malignant tumors. Parenteral administration of this compound followed by irradiation with the appropriate wavelengths of light has been used for the diagnosis and treatment of various epithelial neoplasms. In this study the effects of such treatment on immunological responses were evaluated by examini...

The purpose of the present study was to evaluate communication ability in noise at two signal presentation levels when using acoustic and electronic hearing protection devices (HPDs). Fourteen normal hearing subjects were fitted binaurally with custom acoustic HPDs (ER-15) and custom electronic HPDs (Starkey SA T9). Probe microphone measurements were obtained on 28 ears for three experimental c...

BACKGROUND The antioxidant function of iodine and iodine deficiency as a risk factor of preeclampsia have been previously reported. AIM To analyze the association between iodine deficiency, oxidative stress and antioxidant status with hypertensive disease of pregnancy (HPD). METHOD Fifty-seven pregnant women were recruited in the last trimester of pregnancy; 20 were diagnosed with hypertens...

The main aims of the study were: (1) to enrich the existing knowledge on the mechanism of H2O2, superoxide (O2 ), and protein peroxides (PPO) formation in tumour cells subjected to photodynamic therapy (PDT) with haematoporphyrin derivative (HPD) and (2) to explain the stimulatory effect of heat stress on the generation of O2 –• (a precursor of H2O2 and a very reactive hydroxyl radical) in HPD–...

The cytotoxic effects of hematoporphyrin derivative (HPD) on Friend erythroleukemic cells were studied. Upon binding of the porphyrin to the cells, the fluorescence spectra was shifted from 613 to 633 nm regarding the main band and from 676 to 667 nm concerning the secondary band. The kinetics of HPD binding was then determined. Maximum binding already occurred at 60 s after exposure of the cel...

Exponentially growing melanoma cells of the line FME were incubated with hematoporphyrin derivative (HpD) for 1 and 18 h and subsequently exposed to light in the presence of HpD. Quantitative changes in the expression of the melanoma-associated surface antigen p250 recognized by the monoclonal antibody 9.2.27 were studied by flow cytometry. Treatment with HpD and light resulted in no immediate ...

The synthesis and tissue-localizing ability of [14C]- and [3H]hematoporphyrin derivative (HPD) in mice have been described. Tissue levels and distributions were the same for both radioactive compounds, indicating that in vivo tritium exchange did not occur with [3H]HPD. The amount of [14C]HPD or [3H]HPD which localized in the transplanted tumor tissue of mice at various times following i.p. inj...