Using the statistical analysis of genetic variation, we have developed a high-resolution genetic map of recombination hotspots and recombination rate variation across the human genome. This map, which has a resolution several orders of magnitude greater than previous studies, identifies over 25,000 recombination hotspots and gives new insights into the distribution and determination of recombin...

In humans, the rate of recombination, as measured on the megabase scale, is positively associated with the level of genetic variation, as measured at the genic scale. Despite considerable debate, it is not clear whether these factors are causally linked or, if they are, whether this is driven by the repeated action of adaptive evolution or molecular processes such as double-strand break formati...

We present a socio-technical analysis of security of Hotspot and Hotspot 2.0. The analysis focuses is user-centric, and aim at understanding which user action can compromise security in presence of a attacker. We identify research questions about possible factors that may affect user’s security decisions, and propose experiments to answer them.

Recombination plays a crucial role in meiosis, ensuring the proper segregation of chromosomes. Recent linkage disequilibrium (LD) and sperm-typing studies suggest that recombination rates vary tremendously across the human genome, with most events occurring in narrow "hotspots." To examine variation in fine-scale recombination patterns among individuals, we used dense, genome-wide single-nucleo...

For the first time, sulfur dioxide concentration was monitored between 2005 and 2016 over Iran which is among the countries with a high SO2 emission rate in the world. To that end, SO2 column concentration at Planetary Boundary Layer (PBL) from Ozone Monitoring Instrument (OMI) was analyzed. OMI is a sensor onboard the Aura satellite which can measure daily SO2 concentration on the global scale...

Predicting the biological function potential of post-translational modifications (PTMs) is becoming increasingly important in light of the exponential increase in available PTM data from high-throughput proteomics. We developed structural analysis of PTM hotspots (SAPH-ire)--a quantitative PTM ranking method that integrates experimental PTM observations, sequence conservation, protein structure...

Blood vessels in solid tumors are not randomly distributed, but are clustered in angiogenic hotspots. Tumor microvessel density (MVD) within these hotspots correlates with patient survival and is widely used both in diagnostic routine and in clinical trials. Still, these hotspots are usually subjectively defined. There is no unbiased, continuous and explicit representation of tumor vessel distr...

Mutation frequencies vary significantly along nucleotide sequences such that mutations often concentrate at certain positions called hotspots. Mutation hotspots in DNA reflect intrinsic properties of the mutation process, such as sequence specificity, that manifests itself at the level of interaction between mutagens, DNA, and the action of the repair and replication machineries. The nucleotide...

India accounts for the world’s greatest concentration of coal fires which cause several devastating environmental effects. Only Jharia Coal Field (JCF) in Jharkhand (India) contains nearly half of subsurface mine fires (hotspots) in Indian coalfields. Therefore attention is required in this direction for mapping, monitoring and detecting these hotspots. Operational satellite images can be very ...