Advances in Therapy for Hormone Receptor (HR)-Positive, Human Epidermal Growth Factor 2 (HER2)-Negative Advanced Breast Cancer Patients Who Have Experienced Progression After Treatment with CDK4/6 Inhibitors

Background: Breast cancer is the most common cancer in women, containing approximately one third of all illnesses in women. Assessment of molecular markers is valuable in predicting the outcome of disease and decision making for optimal treatment. The purpose of this study was to determine the relationship between estrogen and progesterone receptors with Her-2, Ki67, P53, and clinicopathologica...

Background: While praised for its benefits in treating symptoms related to menopausal changes, hormone replacement therapy (HRT) has been associated with an increased risk hormone-dependent cancer development, particularly endometrial and breast. Few studies have elucidated the relationship between HRT cessation receptor-positive breast proliferation. We report herein, best of our knowledge, fi...

Introduction: The etiology of male breast cancer is unclear, but hormonal levels may play a role in development of this disease. It seems that the risk of male breast cancer related to increased lifelong exposure to estrogen or reduced androgen. The aim of this study was to investigate the expression of the steroid hormone receptors including estrogen receptor (ER) and progesterone receptor (PR...

Several in vitro tests, including transcriptome analysis of neural cells, were performed to assess the capacity 39 pesticides act as thyroid hormone disruptors (THD). Although some elicit a cellular response, which interferes with signaling, we found no evidence that they can receptor agonists or antagonists. We conclude nuclear receptors are not common targets THD, and pesticide neurodevelopme...

Kisspeptin has been demonstrated to affect reproductive cyclicity and the attainment of puberty in multiple species, presumably through its actions on gonadotropin releasing hormone luteinizing hormone. administration causes increased plasma concentrations LH pigs, sheep, rats. The objective this experiment was evaluate changes hypothalamic kisspeptin system throughout estrous cycle gilts. Estr...