introduction: elevated plasma total homocysteine is an independent risk factor for cardiovascular disease and a sensitive marker of vitamin b12 and folate insufficiency. folate and vitamin b12 have a protective effect on cardiovascular disease. this effect may be partly explained by mechanisms independent of homocysteine. this survey is the first population based study to evaluate the plasma to...

The distribution of total plasma homocysteine concentrations in relation to the sex and age is described, in a population of Shiraz, South West of Iran and compared to those reported in other populations.  Two hundred and one healthy males and 201 healthy females aged >15 y were randomly selected.  Total Plasma homocysteine concentrations were measured using high performance liquid chromatograp...

Aim: In this study, we evaluated the clinical and laboratory data of healthy children with vitamin B12 deficiency. The benefits methylmalonic acid (MMA) homocysteine levels difficulties encountered in diagnosing deficiency were pointed out. 
 Materials Methods: A total 70 whose serum cobalamin below 126.5 pg/ml included study. age, gender, B12, urine MMA, plasma homocysteine, white blood c...

elevated total plasma homocysteine (thcy) levels constitute a risk factor for coronary artery disease (cad). a possible relationship was investigated between admission plasma homocysteine level and the angiographic severity and extension of coronary artery disease in patients with cad. this study looks at the relationship between total plasma homocysteine and severity of coronary artery disease...

background homocysteine is a sulfur-containing amino acid which formed (mainly in the liver) during the metabolism of methionine. prior studies indicated the important role of hyperhomocysteinemia in pathogenesis and progression of alcoholic liver disease, liver steatosis and cirrhosis. one of the most important mechanisms by which homocysteine promote the development of hepatic injury is oxida...

BACKGROUND One-carbon metabolism, which is crucial in DNA synthesis and genomic stability, is an interrelated network of biochemical reactions involved in several dietary and lifestyle factors. The development of the homocysteine score using these factors may be useful to reflect the status of one-carbon metabolism in large epidemiologic studies without biologic samples to measure homocysteine ...

BACKGROUND & OBJECTIVES Age related macular degeneration (ARMD) is a leading cause of blindness, particularly in persons above 60 yr of age. Homocysteine is implicated in many ocular diseases including ARMD. This study was undertaken to assess the status and relationship between plasma homocysteine, homocysteine - thiolactone, homocysteinylated protein and copper levels in patients with ARMD. ...