Homer represents a new and diversified family of proteins made up of several isoforms. The presence of Homer isoforms, referable to 1b/c and 2a/b, was investigated in fast- and slow-twitch skeletal muscles from both rat and mouse. Homer 1b/c was identical irrespective of the muscle, and Homer 2a/b was instead characteristic of the slow-twitch phenotype. Transition in Homer isoform composition w...

Shank is a recently described family of postsynaptic proteins that function as part of the NMDA receptor-associated PSD-95 complex (Naisbitt et al., 1999 [this issue of Neuron]). Here, we report that Shank proteins also bind to Homer. Homer proteins form multivalent complexes that bind proline-rich motifs in group 1 metabotropic glutamate receptors and inositol trisphosphate receptors, thereby ...

Homer EVH1 (Ena/VASP Homology 1) domains interact with proline-rich motifs in the cytoplasmic regions of group 1 metabotropic glutamate receptors (mGluRs), inositol-1,4,5-trisphosphate receptors (IP3Rs), and Shank proteins. We have determined the crystal structure of the Homer EVH1 domain complexed with a peptide from mGluR (TPPSPF). In contrast to other EVH1 domains, the bound mGluR ligand ass...

Homer proteins are a family of multifaceted scaffolding proteins that participate in the organization of signaling complexes at the post-synaptic density and in a variety of tissues including striated muscle. Homer isoforms form multimers via their C-terminal coiled coil domains, which allows for the formation of a polymeric network in combination with other scaffolding proteins. We hypothesize...

Homer1a/Vesl-1S is an activity-dependently induced member of the scaffold protein family Homer/Vesl, which is known to link group I metabotropic glutamate receptors (mGluRs) to endoplasmic calcium release channels and to regulate them. Here we studied roles of Homer 1a in inducing long-term depression (LTD) in rat visual cortex slices. Homer 1a protein was injected by diffusion from whole cell ...

BACKGROUND Homer, known as a scaffolding protein that regulates postsynapse signaling in neurons, has been poorly explored in cardiac research. We show the fundamental properties of Homer 1 in mouse heart in association with cardiac ryanodine receptor (RyR), a binding protein of Homer 1. METHODS AND RESULTS Immunohistochemistry of adult mouse heart with Homer 1 antibody showed striated staini...

Renewable systems influence the process of supplying domestic electricity demands. It will be useful to replace the conventional energy generation system by renewable energy sources since the uncontrolled use of fossil fuels is accompanied by global warming and environmental hazards, in addition to the danger of their depletion, and because most of the energy derived from these fuels are used i...

This paper presents generic model of hybrid power system consisting in a combined solution one wind turbine with asynchronous generator and on hydro generator with synchronous machine. This technology was developed by to reduce the cost of supplying electricity in remote communities. The optimal wind penetration (installed wind capacity/peak electrical demand) for this system depends on the sit...

This paper presents the preliminary optimum planning and design of PV-Wind hybrid energy system for a rural area of India. Optimization of any hybrid system is the process of selecting the suitable components and its sizing with proper operation strategy to provide ecofriendly, efficient, reliable and cost effective alternative energy to the society. Hence for design of hybrid system solar radi...