Pachydermoperiostosis or primary hypertrophic osteoarthropathy (HOA) is a rare congenital growth disorder of connective tissue. We report a case of severe myelofibrosis in a patient with HOA. When cultured in vitro, patient bone marrow-derived fibroblasts displayed a high proliferative potential with a shortened doubling time (24 hours v 36 to 48 hours for normal fibroblasts). The role of plate...

Hand osteoarthritis (HOA) is a heterogeneous disease with the involvement of different joints and varying levels of symptoms. Recent studies showed that the prevalence of HOA varied with gender, age and different hand joints. Different prevalence and longitudinal course of radiographic, erosive and symptomatic HOA were also described in the general population. Nevertheless, the accurate influen...

Affiliations of authors: Faculty of Health and Medical Sciences, University of Surrey, Guildford, UK (MLC, FRG, MPR), Department of Medical Epidemiology and Biostatistics, Karolinska Institutet, Stockholm, Sweden (HOA, HG, FW), Department of Epidemiology, Harvard School of Public Health, Boston, MA, USA (HOA), Dana-Farber/Harvard Cancer Center, Boston, MA, USA (HOA), Joint Senior Authors (FRG, ...

Three patients who manifest intrathoracic Hodgkin’s disease and concurrent hyperfrophic osteoarthropathy (HOA) are presented and compared with four similar patients previously noted in the literature. All were childen or young adults. The clinical, roentgenographic and pathologic features of HOA as seen in these patients are similar to the more familiar syndrome appearing in adults. Although pe...

OBJECTIVES Hand osteoarthritis (HOA) is common but little is known about how HOA has impact on disability and quality of life (QoL).We aim to identify important domains of concern among participants suffering from symptomatic HOA in Singapore, representing an Asian socio-cultural context. METHODS A qualitative study using a focus group technique was performed. We ran focus groups stratified b...

Aim: To compare the changes in anterior corneal surface aberration characteristics after small-incision lenticule extraction (SMILE) versus Q-value-guided femtosecond laser-assisted in situ keratomileusis (Q-FS-LASIK) Methods: In this prospective comparative study, 102 patients with myopia and myopic astigmatism were divided between the SMILE and Q-FS-LASIK groups, consisting of 51 patients eac...

OBJECTIVE To compare serum levels of hyaluronic acid (HA) between patients with erosive and non-erosive hand osteoarthritis (HOA), and investigate its association with morphological changes and radiographic progression over 2 years. METHODS Fifty-five women with erosive and 33 women with non-erosive HOA were included in this study. All underwent clinical examination, which included assessment...

BACKGROUND Balance dysfunction is one of the most common problems in people who suffer stroke. To parameterize functional tests standardized by inertial sensors have been promoted in applied medicine. The aim of this study was to compare the kinematic variables of the Functional Reach Test (FRT) obtained by two inertial sensors placed on the trunk and lumbar region between stroke survivors (SS)...

In arthropods, a group of peptides possessing a -Y((SO3H))GHM/LRFamide carboxy-terminal motif have been collectively termed the sulfakinins. Sulfakinin isoforms have been identified from numerous insect species. In contrast, members of this peptide family have thus far been isolated from just two crustaceans, the penaeid shrimp Penaeus monodon and Litopenaeus vannamei. Here, we report the ident...