Benign metastasizing leiomyoma (BML) refers to benign pulmonary neoplasm associated with a previous or coincident history of uterine leiomyomata. We report the case of a 56-year-old postmenopausal woman with a 4-year history of multiple benign leiomyomatous lesions in bilateral lungs and the uterus. The tumor cells from the lungs and uterus were focally immunoreactive for HMB-45 antibody and pr...

Extrarenal angiomyolipomas (ERAMLs) are rare tumors that present as incidentalomas upon imaging for other conditions. Retroperitoneal ERAMLs present a unique challenge from a diagnostic and treatment standpoint as they can mimic other benign and malignant retroperitoneal tumors. We present a case of a 39-year-old female with a 19.3 cm × 13.5 cm × 10.7 cm left extrarenal retroperitoneal mass. Hi...

OBJECTIVE To describe the morphologic spectrum of metastatic malignant melanoma (MM) cells involving the breast and to explore the diagnostic utility of HMB45, Mart-1, Melan-A and T311 (antityrosinase) antibodies in fine needle aspiration material of MM metastatic to the breast. STUDY DESIGN Cytologic material from 21 cases (18 women) was reviewed for cytomorphology (epithelioid, spindled, mi...

Fig. 2. Strong HMB-45 positivity of the tumour cells (×200). Sir, Subungual melanoma is a relatively rare disease with a reported incidence of between 0.7% to 3.5% of all melanoma cases in the general population (1). Most common sites of involvement are the big toe, the thumb and the index and ring fingers, respectively (2–4). Common signs include pigmentation of the nail bed, nail loss, and na...

We report a case of dermal malignant melanoma that stained negatively for commonly done immunostains, HMB-45, and Melan-A. It stained weakly positive for S-100 protein, a less specific marker for melanocytes. The diagnosis was established by strongly positive immunostaining by MITF ( microphthlmia-associated transcription factor). A brief review of the MITF and its usefulness in the diagnosis o...

Background: Heavy menstrual bleeding (HMB) is defined as excessive blood loss which interferes with a woman's physical, social, emotional and/or material quality of life. It can occur alone or in combination other symptoms. Thyroid hormone affects pattern. The objective this study was to evaluate thyroid function women menorrhagia (HMB).Methods: type journal article. Study design- retrospective...

PURPOSE To determine the effects of 16 wk. of beta-hydroxy-beta-methylbutyrate (HMB) administration on age-related changes in functionality and diffusion tensor imaging (DTI) determined myofiber dimensions. METHODS Twelve young (44 wk.), 6 middle-aged (60 wk.), 10 old (86 wk.), and 5 very old (102 wk.) male Fisher-344 rat's body composition and grip strength were assessed at baseline. Followi...

Introduction: Although malignant melanomas (MM) are common in the head and neck region; primary malignant melanoma of the external auditory canal (EAC) is rare.   Case Report: We present the case of a 50-year-old symptomatic man with a malignant melanoma of the external auditory canal, which clinically masqueraded as a haemangioma. The patient subsequently developed extensive loco-regional me...

BACKGROUND Histologic diagnosis of mucosal melanoma of the head and neck is difficult, requiring immunohistochemical stains which are less reliable than in cutaneous lesions. PNL-2 is a novel marker that has not been examined in mucosal melanoma. METHODS Nine formalin-fixed tissue sections of mucosal melanoma were stained with PNL-2, human melanoma black (HMB)-45, Melan-A, S-100, and micropht...

There is no definite morphological distinction between phaeochromocytomas and paragangliomas. We, therefore, attempted to determine the universality and differential utility of a panel of tumour markers for diagnosis in formalin-fixed, paraffin-embedded specimens. Antibodies to neuron-specific enolase (NSE), chromogranin, synaptophysin, Leu-7, neurofilaments, cytokeratins, carcinoembryonic anti...