We report the case of a 59-year-old woman who developed rapid-onset type 1 diabetes associated with a marked increase in anti-glutamic acid decarboxylase antibody titer (317.5 U/ml), mild increase in HbA1c level (6.8%), diabetic ketoacidosis, and cytomegalovirus enterocolitis. She was a heterozygote for HLA class II DRB1*0901-DQA1*03-DQB1*0303, and she had HLA class I A24, which may have contri...

background and aims: vaccine is available, but fetal infection with rubella virus is still a main cause of congenital birth defects and mental retardation in many countries. mass vaccination campaigns and expanded program of immunization (epi) have increased vaccine coverage in the world with a substantial impact on the reduction of rubella infections, such as congenital rubella syndrome (crs)....

this experiment was conducted to determine the effects of myrtle essential oil (meo) on growth performance, carcass characteristics, antibody titer and blood parameters of broiler chickens. a total of 200 ross 308 broiler chickens were allocated to five dietary treatments with four replicates of 10 birds each. dietary treatments were prepared by formulating a corn-soybean meal-based diet free o...

a semi-field study was carried out to evaluate the effect of two medicinal herbs, individually and in combination, on growth performance, carcass traits, nutrient digestibility and immune response of broiler chickens.  a total of 384 one-day-old straight-run arbor acres broiler chickens were allocated into 24 floor pens prepared in a commercial broiler house. pen-groups were fed one of the foll...

background: this study was conducted to determine the efficacy of milk thistle seeds (mtss) in counteracting the toxic effects of aflatoxin b1 (afb1) in a contaminated diet fed to broilers.methods: two dietary inclusion rates of afb1 (0, 0.250 and 500 ppb) and mts (0, 0.5 and 1%) were tested in a 3×3 factorial manner. the effect of nine experimental treatments was assessed using 216 one-d-old r...

Thirty HLA-A2 women with metastatic breast cancer received up to 14 vaccinations with MDA-MB-231-CD80, an HLA-A2 allogeneic breast cancer cell line, which had been lipofected with the cDNA for the CD80 costimulatory molecule. Tumor cells were administered with BCG or GM-CSF as an adjuvant. Sera obtained before and after vaccination were analyzed for antibodies to tumor cell lysate, MUC1, HER2/n...

We performed a two-stage genome-wide association study (GWAS) of antibody titer in 3614 hepatitis B vaccine recipients from Indonesia's Riau Archipelago, leading to the identification of at least three independent signals within the human leukocyte antigen (HLA) complex. These appear to implicate HLA-DR [rs3135363; P= 6.53 × 10(-22); odds ratio (OR) = 1.53, 95% confidence interval (CI) = 1.35-1...

Human antibody response to measles vaccine is highly variable in the population. Host genes contribute to inter-individual antibody response variation. The killer cell immunoglobulin-like receptors (KIR) are recognized to interact with HLA molecules and possibly influence humoral immune response to viral antigens. To expand on and improve our previous work with HLA genes, and to explore the gen...