For opening wedge high tibial osteotomy (OWHTO), it is recommended that the osteotomy line is parallel to the medial tibial posterior slope (TPS) in the sagittal view and that the alignments are simultaneously controlled in the coronal and sagittal views. Here combined computed tomography (CT)-based and image-free navigation systems were used for intraoperative reference during OWHTO. Using the...

INTRODUCTION There are few specific reports of late medial instability after total knee arthroplasty (TKA). We described two cases of late medial instability of the knee due to hip disease with osteoarthritis or rheumatoid arthritis after TKA, which required revision TKA. PRESENTATION OF CASES An 82-year-old woman experienced right femoral neck fracture due to a fall that required conservativ...

Background and purpose - Medial unicompartmental knee arthroplasty (UKA) is undertaken in patients with a passively correctable varus deformity. We investigated whether restoration of natural soft tissue tension would result in a lower limb alignment similar to that of the contralateral unaffected lower limb after mobile-bearing medial UKA. Patients and methods - In this retrospective study, hi...

Proteolytic cleavage of single-chain high molecular weight kininogen (HK) by kallikrein releases the short-lived vasodilator bradykinin and leaves behind 2-chain high molecular weight kininogen (HKa) that has been previously reported to exert antiadhesive properties as well as to bind to the urokinase receptor (uPAR) on endothelial cells. In this study we defined the molecular mechanisms for th...

Background. Hip and knee arthroplasty (HKA) is a common surgical procedure. One of the diseases that negatively affect results these operations diabetes. The aim study: to determine effectiveness safety combined multimodal low-opioid anesthesia with dexmedetomidine sedation in patients undergoing HKA concomitant diabetes mellitus. Materials methods. In total, study included 45 who underwent HKA...

Frontal malalignment of the lower limbs has been shown to be closely linked to the onset and progression of knee osteoarthritis. Restoration of a satisfactory alignment after total knee arthroplasty has a positive impact on implant durability and functional result. An angle measurement commonly used to assess this alignment is the HKA angle (hipknee-ankle). It is measured on a full length AP ra...

Angiogenesis, the synthesis of new blood vessels from preexisting vessels, plays a critical role in normal wound healing and tumor growth. HKa (cleaved high molecular weight kininogen) is an endogenous inhibitor of angiogenesis formed by the cleavage of kininogen on endothelial cells. Ferritin is a protein principally known for its central role in iron storage. Here, we demonstrate that ferriti...

Objective Foot and/or ankle (F/A) problems may be encountered in medial uni-compartmental knee (UKA) patients postoperatively due to the limb alignment changes and alterations weight bearing of F/A. This study aimed evaluate risk factors incidence foot arthroplasty patients. Methods Patients who underwent UKA between 2016 2019 our clinic were evaluated presence F/A was recorded. Radiologic eval...

F erritin is a protein whose principal role within cells is the storage of iron in a nontoxic, but bioavailable, form. The assembled ferritin molecule, often referred to as a nanocage, can store up to 4,500 atoms of iron (for review see ref. 1). In contrast to cytosolic ferritin, serum ferritin is relatively iron-poor and may contain only a few atoms of iron. Ferritin does not have an obvious l...

Wang, Shujie, Muneer G. Hasham, Irma IsordiaSalas, Alexander Y. Tsygankov, Robert W. Colman, and Yan-Lin Guo. Upregulation of Cdc2 and cyclin A during apoptosis of endothelial cells induced by cleaved high-molecular-weight kininogen. Am J Physiol Heart Circ Physiol 284: H1917–H1923, 2003;10.1152/ajpheart.00861.2002.—We (8) reported that the cleaved high-molecular-weight kininogen (HKa) and its ...