Hypoxia stimulates hepatocellular carcinoma (HCC) cell growth via hexokinase (HK) II induction, and alternatively, HK II inhibition induces apoptosis by activating mitochondrial signaling. This study was to investigate whether the induction of HK II by hypoxia is associated with enhanced mitochondrial stability and to confirm the apoptosis-inducing efficacy of HK II inhibitor in an in vivo mode...

While disruption of energy production is an important contributor to renal injury, metabolic alterations in sepsis-induced AKI remain understudied. We assessed changes in renal cortical glycolytic metabolism in a mouse model of sepsis-induced AKI. A specific and rapid increase in hexokinase (HK) activity (∼2-fold) was observed 3 h after LPS exposure and maintained up to 18 h, in association wit...

Algorithm 1 gives the procedure used to optimize the background motion model as described in Section 4. GetWeights computes the residuals from the given model Hk and uses Equation 3 to compute the weight for each track in T . Similarly, GetCost computes the total cost (Equation 4). Finally, WLS uses a weighted-least-squares variant of the four-point algorithm to re-estimate each homography Hk i...

In this paper we derive a new dynamic friction force model for the longitudinal road/tire interaction for wheeled ground vehicles. The model is based on a dynamic friction model developed previously for contact-point friction problems, called the LuGre model [7]. By assuming a contact patch between the tire and the ground we develop a partial differential equation for the distribution of the fr...

the incremental sheet metal forming (ismf) process is a new and flexible method that is well suited for small batch production or prototyping. this paper studies the use of the finite element method in the incremental forming process of aa1050 sheets to investigate the influence of tool diameter, vertical step size, and friction coefficient on forming force, spring-back, and thickness distribut...

Objective: To study the antianaphylactic, antihistaminic and mast cell stabilization activity of Bresol (HK-07) in experimental animals. Materials and Methods: Experimental studies of Bresol (HK-07) were evaluated using Wistar rats and Duncan Hartley guinea pigs. The antianaphylactic activity of Bresol (HK-07) was investigated in rats using active anaphylaxis model. The effect of Bresol (HK-07)...

In this paper, a SDOF system with nonlinear viscous friction under harmonic excitation is studied. A nonlinear viscous friction model is built as an exponential expansion of the relative slip velocity. According to the adaptive control theory, an adaptive controller for the friction compensation of the SDOF system with nonlinear viscous friction is put forward by using the model-based parameter...

BACKGROUND Cultures of human proximal tubule cells have been widely utilized to study the role of EMT in renal disease. The goal of this study was to define the role of growth media composition on classic EMT responses, define the expression of E- and N-cadherin, and define the functional epitope of MT-3 that mediates MET in HK-2 cells. METHODS Immunohistochemistry, microdissection, real-time...

many studies have been conducted focusing on the effects of friction coefficient or texture depth on the highway accident risk. however, combined effects of these parameters have not been still addressed. in this research the interaction between friction coefficient, texture depth and accident rate in 30 freeway sections were examined. the accident data were gathered and an apparatus was design...