In mammals, hexokinase (HK) is strategically located at the outer membrane of mitochondria bound to the porin protein. The mitochondrial HK is a crucial modulator of apoptosis and reactive oxygen species generation. In plants, these properties related to HK are unknown. In order to better understand the physiological role of non-cytosolic hexokinase (NC-HK) in plants, we developed a purificatio...

The objective of this study was to investigate the efficacy of an Electroencephalography (EEG)-based Motor Imagery (MI) Brain-Computer Interface (BCI) coupled with a Haptic Knob (HK) robot for arm rehabilitation in stroke patients. In this three-arm, single-blind, randomized controlled trial; 21 chronic hemiplegic stroke patients (Fugl-Meyer Motor Assessment (FMMA) score 10-50), recruited after...

We shortly review recent work interpreting the quotient ζ(s− 1)/ζ(s) of Riemann zeta functions as a dynamical zeta function. The corresponding interaction function (Fourier transform of the energy) has been shown to be ferromagnetic, i.e. positive. On the additive group Gk := (Z/2Z), with Z/2Z = ({0, 1},+). we set inductively h0 := 1, hk+1(σ, 0) := hk(σ) and hk+1(σ, 1) := hk(σ) + hk(1− σ), (1) ...

Example 3. For k′/k a finite separable extension and H any linear algebraic k-group, we have H ↪−→ Rk′/k(Hk′) =: H ′, where Rk′/k(Hk′) is the Weil restriction functor (which is representable by a linear algebraic k-group). This functor is defined by Rk′/k(Hk′)(A) = Hk′(A⊗k k′), so the injection H ↪−→ Rk′/k(Hk′) is given by sending a k-morphism SpecA→ H to its base change by k′. Then we have [H ...

3-Hydroxykynurenine (3-HK) is a tryptophan metabolite whose level in the brain is elevated under several pathological states including Huntington's disease. In the present study, we examined the possible toxicity of 3-HK by injection of this substance into rat brain. Intrastriatal injection of 3-HK (50 nmol) induced tissue damage around the injected site. Quinolinic acid (QA) at 200 nmol also i...

Low and high molecular weight kininogens (LK and HK), containing 409 and 626 amino acids with masses of approximately 65 and 120 kDa after glycosylation, respectively, are coded by a single gene mapped to the human chromosome 3 by alternative splicing of the transcribed mRNA. The NH2-termini Glu1-Thr383 region, identical in LK and HK, contains bradykinin (BK) moieties Arg363-Arg371. LK, HK and ...

BACKGROUND Hexokinase-2(HK-2) plays dual roles in glucose metabolism and mediation of cell apoptosis, making it an attractive target for cancer therapy. Chrysin is a natural flavone found in plant extracts which are widely used as herb medicine in China. In the present study, we investigated the antitumor activity of chrysin against hepatocellular carcinoma (HCC) and the role of HK-2 played for...

introduction: although hippocampus is the most famous brain area involved in temporal lobe epilepsy, hippocampal kindling (hk) develops very slowly. hence, rapid kindling is usually preferred to the traditional kindling and it is widely used. in this article we aimed at finding the optimal stimulus pattern, which yields the fastest hk rate. methods: stimulus patterns with different duration (2,...

PURPOSE To detect endogenous substance P (SP) and neurokinin receptor 1 (NK1R) in cultured human corneal epithelial cells (HE) and cultured human keratocytes (HK). METHODS Messenger RNA (mRNA) expression of SP and endogenous SP in HE and HK was investigated by reverse transcription-polymerase chain reaction (RT-PCR) and enzyme-linked immunosorbent assay. mRNA expression of NK1R in HE and HK w...