WRN protein loss causes Werner syndrome (WS), which is characterized by premature aging as well as genomic and telomeric instability. WRN prevents telomere loss, but the telomeric protein complex must regulate WRN activities to prevent aberrant telomere processing. Telomere-binding TRF2 protein inhibits telomere t-loop deletion by blocking Holliday junction (HJ) resolvase cleavage activity, but...

This paper presents three hybrid metaheuristic algorithms that further improve the two hybrid differential evolution (DE) metaheuristic algorithms described in Liao [1]. The three improved algorithms are: (i) MDE′–HJ, which is a modification of MA–MDE′ in Liao [1] by replacing the random walk with direction exploitation local search with the Hooke and Jeeves (HJ) method; (ii) MDE′–IHS–HJ, which...

We study the large time asymptotic speeds (turbulent flame speeds sT ) of the simplified Hamilton-Jacobi (HJ) models arising in turbulent combustion. One HJ model is G-equation describing the front motion law in the form of local normal velocity equal to a constant (laminar speed) plus the normal projection of fluid velocity. In level set formulation, G-equations are HJ equations with convex (L...

BACKGROUND The aim of this retrospective study was to evaluate the peri-operative and long-term outcome after early repair with a hepaticojejunostomy (HJ). METHODS Between 1995 and 2010, a nationwide, retrospective multi-centre study was conducted. All iatrogenic bile duct injury (BDI) sustained during a cholecystectomy and repaired with HJ in the five Hepato-Pancreatico-Biliary centres in De...

The heterojunction (HJ) solar cell is one of the best possible options to upgrade conventional single homo-junction c-Si cell. In this work, a HJ based on crystalline silicon (c-Si) wafer with zinc oxide (ZnO) designed reduce loss power conversion owing reflection incident photons by top surface silicon. A PC1D simulation used evaluate optimum numerical value key photovoltaic parameters for HJ-...

Homologous DNA recombination promotes genetic diversity and the maintenance of genome integrity, yet no enzymes with specificity for the Holliday junction (HJ)-a key DNA recombination intermediate-have been purified and characterized from metazoa or their viruses. Here we identify critical structural elements of RuvC, a bacterial HJ resolvase, in uncharacterized open reading frames from poxviru...

Eukaryotic Holliday junction (HJ) resolvases have attracted much attention recently with the identification of at least three distinct proteins that can cleave model HJs in vitro. However, the specific DNA structure(s) that these proteins act upon in the cell is unknown. Here, we describe a system in budding yeast to directly and quantitatively monitor in vivo HJ resolution. We found that Yen1 ...

In this paper, we consider first order Hamilton-Jacobi (HJ) equations posed on a “junction”, that is to say the union of a finite number of half-lines with a unique common point. For this continuous HJ problem, we propose a finite difference scheme and prove two main results. As a first result, we show bounds on the discrete gradient and time derivative of the numerical solution. Our second res...

Several chaotic properties of cyclic permutation maps are considered. Cyclic refer to p-dimensional dynamical systems the form φ(b1,b2,⋯,bp)=(up(bp),u1(b1),⋯,up−1(bp−1)), where bj∈Hj (j∈{1,2,⋯,p}), p≥2 is an integer, and Hj (j∈{1,2,⋯,p}) compact subintervals real line R=(−∞,+∞). uj:Hj→Hj+1(j=1,2,…,p−1) up:Hp→H1 continuous maps. Necessary sufficient conditions for a class have Li–Yorke chaos, di...