Keeling, J. W., and Harries, J. T. (1973). Archives of Disease in Childhood, 48, 350. Intestinal malabsorption in infants with histiocytosis X. An infant with histiocytosis X had unequivocal evidence of intestinal malabsorption which was associated with histiocytic infiltration of the small intestine. 11 other fatal cases where histological material from the gastrointestinal tract was available...

Langerhans’ cell histiocytosis may cause irreversible respiratory failure due to progressive destruction of lung parenchyma and widespread cystic change. Transplantation oVers a therapeutic option. A case is described of recurrence of Langerhans’ cell histiocytosis which was associated with deterioration in lung function four years following bilateral lung transplantation. Patients transplanted...

In three patients with histiocytosis X of bone with orbital involvement, CT scans were reviewed. Consistent findings included a destructive lesion of the lateral wall of the orbit with a large soft-tissue component that extended into the extraconal space, the ocular adnexa, and the infratemporal fossa. The greater wing of the sphenoid was eroded in all cases, with epidural extension into the mi...

Langerhans' cell histiocytosis of the lung can be part of a multisystem disorder or an isolated disorder. Ninety percent of adult patients with Langerhans' cell histiocytosis of the lung are smokers. This article reports a case of Langerhans' cell histiocytosis presenting with haemoptysis. The diagnostic signs on chest X-ray, high-resolution computed tomography, and histology are highlighted, f...

INTRODUCTION Langerhans cell histiocytosis (LCH) is a proliferative disorder of histiocytes in multiple organs. Langerhans cell histiocytosis involves bones, skin, lung and other organs. CASE PRESENTATION This study describes a seven-month-old Iranian girl who presented with skin rash and cervical lymphadenopathy. Langerhans cell histiocytosis was suspected when it was associated with anemia,...

L angerhans’ cell histiocytosis (LCH), formerly known as histiocytosis X, is one of a group of poorly understood diseases of histiocytes. The clinical spectrum of disease ranges from the chronic, localized form to an acute leukemia-like disease with a fatal outcome. Alfred Hand was the first to report a case of histiocytosis in 1893.1 Later, in 1941, Farber described this condition when reporti...