Background Due to geographic isolation and border controls, Aotearoa New Zealand attained high levels of population coronavirus disease-19 (COVID-19) vaccination before widespread community transmission Omicron variant COVID-19 in early 2022. This provides a unique opportunity examine outcomes people with rheumatic diseases immunologically naive COVID-19. Objectives study aims describe the infe...

Background: Pain is a hallmark symptom of hand osteoarthritis (OA). A subset people with OA display centrally driven pain characteristics. by person-related factors, but how comorbidities are related to the experience undetermined. Changes in pathophysiology and levels for instants low-grade inflammation, might explain link. Objectives: The purpose this study was determine whether burden or ind...

Background Neutralising anti-drug antibodies (ADAb) are a problem in treatment with TNF-inhibitors (TNFi). Prospective data needed to better understand how ADAb formation impacts safety and outcomes of TNFi. Proactive therapeutic drug monitoring (TDM) allows for timely detection this strategy may have role reducing the negative clinical consequences ADAb. Objectives To explore temporal relation...

Background Limited data is available regarding long-term effectiveness of SARS-CoV-2 vaccines in patients with immune-mediated inflammatory diseases (IMIDs) on immunosuppressive therapy. Whether the persistence vaccine-induced humoral immunity against differs between this patient population and general public currently unknown. Objectives To compare anti-Spike antibodies following two vaccine d...

Background: Juvenile idiopathic arthritis (JIA) can cause considerable pain and disability in childhood adulthood. The number of studies exploring the efficacy medications adult JIA patients is limited. Methotrexate (MTX) a commonly used medication for this patient group. Objectives: To explore effects MTX monotherapy (mono) on disease activity diagnosed with JIA, compared to weighted rheumatoi...

Background: Immunogenicity is related to loss of efficacy and safety TNFα inhibitors frequently observed early in the treatment course. The highest rate anti-drug antibody (ADAb) formation has been reported for infliximab (IFX). 1 Knowledge about risk factors immunogenicity might contribute better handling this problem clinical practice. Objectives: To identify ADAb during phase IFX treatment. ...

Background: Incidence of rheumatoid arthritis (RA) in Norway has not been evaluated a nationwide setting. Objectives: To estimate the incidence RA and real-life penetration disease-modifying antirheumatic drug (DMARD) use Norway. Methods: The Norwegian Cardio-Rheuma register comprises pseudonymized data from registries including total population ≥18 years during 2008-2017. Demographic socioecon...

Background Hand osteoarthritis (OA) pain is characterized as heterogeneous and multifactorial. Different patterns may be explained by underlying phenotypes, which previously have not been explored. Objectives Using the biopsychosocial framework, we aimed to identify possible hand OA phenotypes explore associations with intensity change in during a four-year follow-up. Methods Latent class analy...

Background T cells are critical for control of viral infection with SARS-CoV-2, but knowledge is lacking on cellular immune responses following repeated vaccination and breakthrough in immunosuppressed patients. Objectives To examine longitudinal cell across diagnoses, vaccine series COVID-19 patients tumor necrosis factor inhibitors (TNFi). Methods The prospective, observational Nor-vaC study ...

Abstract Background Olorofim, the first orotomide antifungal, selectively inhibits fungal dihydroorotate dehydrogenase (DHODH), a key enzyme in pyrimidine biosynthesis. Olorofim is active against Aspergillus (including azole-resistant and cryptic species), resistant moulds (e.g., Lomentospora prolificans, Scopulariopsis) dimorphic fungi Coccidioides). The drug given orally cleared by multiple C...