BACKGROUND APOL1 genetic variants confer an increased risk for kidney disease. Their associations with cardiovascular disease (CVD) are less certain. We aimed to compare the prevalence of subclinical CVD and incidence of atherosclerotic CVD and heart failure by APOL1 genotypes among self-identified black participants of MESA (Multi-Ethnic Study of Atherosclerosis). METHODS AND RESULTS Cross-s...

OBJECTIVE Estrogen plays a key role in breast cancer development and functionally relevant genetic variants within the estrogen metabolic pathway are prime candidates for a possible association with breast cancer risk. We investigated the independent and the combined effects of commonly occurring polymorphisms in four genes encoding key proteins of estrogen metabolic pathway on their potential ...

BACKGROUND It is believed that Human Papillomavirus (HPV) and Human Immunodeficiency Virus coinfection contributes to increase the risk for cervical intraepithelial injuries. Several factors may contribute to cervical cancer (CC) development, including genetic variants such as TP53 and MDM2 gene polymorphisms. MATERIALS AND METHODS A hundred HIV-infected women were examined for HPV detection ...

results hepatitis b surface antigen (hbsag) was found in 122/3000 (4.1%) prisoners. hepatitis b e antigen (hbeag), anti-hiv, anti-hcv and anti-hiv/anti-hcv were detected in 52/122 (42.6%), 12/122 (10%), 22/122 (18%) and 3/122 (2.4%) prisoners, respectively. the hbv-dna was found in 115/122 (94.3%) prisoners. the most high risk behavior was to utilize the collaborative syringe by injecting drug ...

BACKGROUND Single-nucleotide polymorphisms in the promoter region of the FAS and FASLG may alter the transcriptional activity of these genes. We therefore investigated the association between the FAS and FASLG polymorphisms and risk for second primary malignancy (SPM) after index squamous cell carcinoma of the head and neck (SCCHN). METHODS We used log-rank test and Cox proportional hazard mo...

BACKGROUND In the literature, data on the prevalence of human papillomavirus (HPV) infection in men vary significantly and the exact distribution of specific genotypes is still unclear. As infections usually occur without symptoms, men might only attend their hospital clinic when they have a specific concern, being in most cases genital warts (condylomas), which are often caused by low-risk HPV...

OBJECTIVE Human papillomavirus (HPV) genotypes and their relative prevalences were determined in a cohort of 310 sexually active women in Trinidad, West Indies. METHODS Cervical samples were collected with Ayre's spatulas and endocervical brushes. Samples were used for the conventional Papanicolaou test and for determining HPV genotypes by amplification of a section of the viral L1 gene, foll...

The human papillomavirus (HPV) family are a group of DNA viruses that are diverse and ubiquitous. There are about 100HPV genotypes known to infect humans, of which about 40 infect the anogenital epithelium. These genotypes can be further divided into risk categories depending on their association with cancer. Low-risk genotypes (such as HPV 6 and 11) are responsible for over 90% of genital wart...

AIM To investigate the pre-vaccination epidemiology of genital human papillomavirus (HPV) infections and genotypes in women with abnormal cytology in Nagasaki, Japan. MATERIAL AND METHODS We performed Pap smear tests, biopsies and HPV genotype testing in Nagasaki Prefecture from August 2007 through November 2009. RESULTS During the study period, serial samples of uterine cervical specimens ...