Chromatin immunoprecipitation followed by high throughput sequencing (ChIP-Seq) has been successfully used for genome-wide profiling of transcription factor binding sites, histone modifications, and nucleosome occupancy in many model organisms and humans. Because the compact genomes of prokaryotes harbor many binding sites separated by only few base pairs, applications of ChIP-Seq in this domai...

Positron emission tomography (PET)/computed tomography (CT), which combines the advantages of high sensitivity and specificity of PET and high resolution of CT, is a unique tool for cancer management. PET/CT has been widely used in cancer diagnosis and treatment. The article reviews the recent applications of PET/CT in radiation oncology, with a focus on (18)F-fluorodeoxyglucose (FDG)-PET/CT, a...

Positron emission tomography (PET) and magnetic resonance imaging (MRI) are widely used in vivo imaging technologies with both clinical and biomedical research applications. The strengths of MRI include high-resolution, high-contrast morphologic imaging of soft tissues; the ability to image physiologic parameters such as diffusion and changes in oxygenation level resulting from neuronal stimula...

introduction: an efficient method of tomographic imaging in nuclear medicine is positron emission tomography (pet). compared to spect, pet has the advantages of higher levels of sensitivity, spatial resolution and more accurate quantification. however, high noise levels in the image limit its diagnostic utility. noise removal in nuclear medicine is traditionally based on fourier decomposition o...

Silicon photomultiplier (Si-PM) is a promising photodetector for PET for the use in magnetic resonance imaging (MRI) systems because it is insensitive to static magnetic fields. Si-PM is also a promising for high resolution PET systems due to its small channels and high gain.  We have developed several Si-PM based imaging systems for molecular imaging. First, we developed a high resolution Si-...

Considering the high cost of dedicated small-animal positron emission tomography/computed tomography (PET/CT), an acceptable alternative in many situations might be clinical PET/CT. However, spatial resolution and image quality are of concern. The utility of clinical PET/CT for small-animal research and image quality improvements from super-resolution (spatial subsampling) were investigated. Na...