Through sequence-based classification, this paper tries to accurately predict the DNA binding sites of transcription factors (TFs) in an unannotated cellular context. Related methods in the literature fail to perform such predictions accurately, since they do not consider sample distribution shift of sequence segments from an annotated (source) context to an unannotated (target) context. We, th...

OBJECTIVE To assess the factor structure of the Chinese version of the Tampa Scale for Kinesiophobia (TSK). DESIGN Chinese patients with chronic pain attending either orthopaedic specialist services (n = 216) or multidisciplinary specialist pain services (n = 109) participated in this study. METHODS Subjects completed the Chinese version of TSK, The Chronic Pain Grade Questionnaire, Hospita...

In Xenopus, ectodermal patterning depends on a mediolateral gradient of BMP signaling, higher in the epidermis and lower in the neuroectoderm. Neural crest cells are specified at the border between the neural plate and the epidermis, at intermediate levels of BMP signaling. We recently described a novel secreted protein, Tsukushi (TSK), which works as a BMP antagonist during chick gastrulation....

Subjective thermal comfort plays a critical role in body temperature regulation since this represents the primary stimulus for behavioral thermoregulation. Although both core (Tc) and skin-surface (Tsk) temperatures are known afferent inputs to the thermoregulatory system, the relative contributions of Tc and Tsk to thermal comfort are unknown. We independently altered Tc and Tsk in human subje...

Heat stress and hydration may both alter plasma volume (PV) responses during acute exercise; potential interactions have not been fully studied. The purpose of this study was to determine the effect of graded elevations in skin temperature (Tsk) on PV changes during steady-state exercise under conditions of euhydration (EU) and hypohydration (HYPO, -4% of body mass). Thirty-two men (22 ± 4 yr) ...

Despite the popularity and practical importance of fuzzy inference system (FIS), use an FIS model as n -ary aggregation function, which is characterized by both monotonicity boundary properties, yet to be established. This because research on ensuring that models satisfy property, i.e., monoton...

This work is focused on creating fuzzy granular classification models based on general type-2 fuzzy logic systems when consequents are represented by interval type-2 TSK linear functions. Due to the complexity of general type-2 TSK fuzzy logic systems, a hybrid learning approach is proposed, where the principle of justifiable granularity is heuristically used to define an amount of uncertainty ...

BACKGROUND The Tampa Scale of Kinesiophobia (TSK) that was developed in 1990 is a 17 item scale originally developed to measure the fear of movement related to chronic lower back pain. OBJECTIVE To review the literature regarding TSK and neck pain, perceived disability and range of motion of the cervical spine. METHODS Medline, MANTIS, Index to Chiropractic Literature and CINAHL were search...

Systemic sclerosis (scleroderma, SSc) is an autoimmune, connective tissue disorder that is characterized by impaired vascular function, increased oxidative stress, inflammation of internal organs, and impaired angiogenesis. Tight skin mice (Tsk(-/+)) have a defect in fibrillin-1, resulting in replication of many of the myocardial and vascular features seen in humans with SSc. D-4F is an apolipo...