High-frequency percussive ventilation (HFPV) has demonstrated a potential role as a rescue option for refractory acute respiratory distress syndrome and as a method for improving inhalation injury outcomes. Nevertheless, there is a lack of literature examining the practical application of HFPV theory toward either improving gas exchange or preventing possible ventilator-induced lung injury. Thi...

High-frequency ventilation (HFV) has been advocated to reduce lung injury and chronic lung disease (CLD) in preterm infants. Several randomized controlled trials have compared HFV with conventional mechanical ventilation (CMV) in preterm and term infants. This review first discusses animal data pertinent to optimizing the application of HFV in preterm infants. Second, a meta-analysis of all ran...

Lung injury remains an important cause of morbidity among newborns who require assisted ventilation. Studies in immature animal models of respiratory distress syndrome (RDS) have shown that positivepressure ventilation with large tidal volumes damages pulmonary capillary endothelium, alveolar and airway epithelium, and basement membranes. This mechanical damage results in leakage of fluid, prot...

conclusions treatment of neonatal respiratory failure with high rate mechanical ventilation may reduce some complications. results intraventricular hemorrhage (ivh) and air leak (e.g. pneumothorax) were less in hfppv group than conventional group (p = 0.012 and p = 0.038). the mean time needed for mechanical ventilation was lower in hfppv group, but this difference was not statistically signifi...