The hepatoprotective activity of the ethanolic extract of the rhizomes of Costus speciosus (Koenig) Sm. was studied on carbon tetrachloride treated rats. The extract registered a significant fall in the levels of serum glutamyl oxalacetic acid transaminase (SGOT), serum glutamyl pyruvate transaminase (SGPT), alkaline phosphatase (ALKP), serum bilirubin (SBLN) and liver inflammation supported by...

Purpose: The effects of oral administration of ethyl acetate, ethanol and aqueous extracts of Adenema hyssopifolium G.Don (Gentianaceae) on carbon tetrachloride-induced liver disorders were investigated. Methods: Rats were individually treated daily with 300 and 600 mg/kg dose of either ethyl acetate, ethanol or aqueous extracts of A. hyssopifolium, respectively, following induction of liver da...

BACKGROUND Melastoma malabathricum L. (Melastomaceae) is a small shrub with various medicinal uses. The present study was carried out to determine the hepatoprotective activity of methanol extract of M. malabathricum leaves (MEMM) against the paracetamol-induced liver toxicity in rats model. METHODS The respective chemicals and herbal solutions (10% DMSO, 200 mg/kg silymarin or MEMM (50, 250 ...

this study was designed to evaluate the hepatoprotective and antioxidant activity of methanol extract of lippia nodiflora (meln) in acute experimental liver injury induced by paracetamol (750mg/kg, b.w). meln at the doses of 200 and 400mg/kg, p.o was administered for 7 days and biochemical parameters such as serum glutamate oxaloacetate transaminase (sgot), glutamate pyruvate transaminase (sgpt...

The different extracts of Apium graveolens Linn. (Apiaceae) and Croton oblongifolius Roxb. (Euphorbiaceae) were tested for their hepatoprotective activity against CCl(4) induced hepatotoxicity in albino rats. The degree of protection was measured by using biochemical parameters like serum transaminases (SGOT and SGPT), alkaline phosphatase, total protein and albumin. The methanolic extracts sho...

Bauhinia variegata (Leguminosae) commonly known as Kachnar, is widely used in Ayurveda as tonic to the liver. The present work was carried out to assess the potential of Bauhinia variegata bark as hepatoprotective agent. The hepatoprotective activity was investigated in carbon tetrachloride (CCl(4)) intoxicated Sprague-Dawley rats. Bauhinia variegata alcoholic Stem Bark Extract (SBE) at differe...

This study was designed to determine the antioxidant and hepatoprotective effect of nbutanol soluble fractions of Albizzia lebbeck The various extracts were prepared and extracts containing flavanoids, tannins and saponins (Methanolic extract) was selected for isolation of chemical constituents. nbutanol soluble fractions of extract (BFALB) and leaf extract (BFALL) were selected for screening o...

Hepatoprotective activity of hydroalcoholic extract of Luffa acutangula (HAELA) against carbon tetrachloride (CCl4) and rifampicin-induced hepatotoxicity in rats was evaluated and probable mechanism(s) of action has been suggested. Administration of standard drug- silymarin and HAELA showed significant hepatoprotection against CCl4 and rifampicin induced hepatotoxicity in rats. Hepatoprotective...

The aim of the present study was to isolate hepatoprotective component from Urtica dioica Linn. (whole plant) against CCl4-induced hepatotoxicity in-vitro (HepG2 cells) and in-vivo (rats) model. Antioxidant activity of hydro alcoholic extract and its fractions petroleum ether fraction (PEF), ethyl acetate fraction (EAF), n-butanol fraction (NBF) and aqueous fraction (AF) were determined by DPPH...

Treatment of diseases with natural remedies is gaining popularity because of its fewer side effects.   A systemic and scientific investigation of aqueous extract of Euphorbia tirucalli for its antioxidant and hepatoprotective potential against carbon-tetrachloride-induced hepatic damage in rats was carried out . Antioxidant property was assessed by using reducing property, superoxide a...