introduction: hepatocellular carcinoma (hcc) is sixth common cancers worldwide and predominant in asia and africa. a number of evidence suggests a possible role of midkine (mdk) and α-fetoprotein (afp) in the pathogenesis of hepatocellular carcinoma (hcc). materials and methods: we studied mdk and afp in patients with hcc or in healthy controls. mdk and afp was measured by enzyme linked immunos...

Background: Hepatocellular carcinoma (HCC) is common all over the world as well as Iran. The incidence of HCC is higher in hepatitis B carriers and it is highly recommended to periodically screen these patients by serum alpha-fetoprotein (AFP) and liver ultrasound (US) every 6 months. We explore the diagnostic accuracy and the performance of (AFP) in cases of hepatitis B carriers as a scree...

Background: Hepatocellular carcinoma (HCC) is the one of most common cancers and lethal diseases in world. SORT1 a neuronal type-1 membrane protein member Vps10p-domain receptor family, which was abundantly expressed cells. However, effect on HCC progression remains unclear hepatocellular carcinoma. Material methods: Analysis various public omics datasets revealed that overexpressed HCC. Next, ...

Background and AimsStress granules (SGs) as membrane-less cytoplasmic foci formed in response to unfavorable external stimuli could promote cancer cells adapt hostile environments. Hepatocellular carcinoma (HCC) is prone be highly aggressive once diagnosed, which markedly reduces patient survival time. Therefore, it crucial develop valid diagnostic markers prognosticate HCC prognosis, promotes ...

Background: Human leukocyte antigen (HLA)-G is a nonclassical HLA class I molecule with modulatory effects on NK and T cells. Because HLA-G expression is frequently detected in different solid tumors, it may be involved in tumor immune evasion. Objective: This study was designed to elucidate the prognostic value of HLA-G in hepatocellular carcinoma (HCC) and pancreatic adenocarcinoma (PADC). Th...

Abstract Some studies have reported that activated ribosomes are positively associated with malignant tumors, especially in hepatocellular carcinoma (HCC). The RNA-binding protein PNO1 is a critical ribosome rarely human tumors. This study aimed to explore the molecular mechanisms of HCC. Using 150 formalin-fixed and paraffin-embedded samples 8 fresh samples, we found high expression HCC tumor ...

Hepatocellular carcinoma (HCC) is one of the most common malignant tumours and second frequent cause cancer-related death worldwide. The aim this review to identify whether phytotherapy has an effect over treatment HCC or if it suitable as a combination with chemotherapy. A systematic was performed in order offer current information use HCC. We conducted electronic search articles published Eng...

The G protein-coupled receptor, class C, group 5, member A (GPRC5A) plays a key role in various diseases, but its effect on hepatocellular carcinoma (HCC) and the potential underlying mechanisms remains unclear. In present study, we explored of GPRC5A progression HCC further mechanism action. results revealed that expression was lower tissues cells. Overexpression suppressed proliferation epith...

Hepatocellular Carcinoma (HCC) is a leading cause of cancer-related deaths worldwide [...]

Objective(s): Hepatocellular carcinoma (HCC) is one of the leading fatal neoplasms and the most common primary liver malignancy worldwide. Peptide hormone ANGPTL8 (betatrophin) may act as an important regulator in HCC development through the Wnt/β-catenin pathway. We aimed to evaluate the effects of recombinant ANGPTL8 on Wnt/β-catenin signaling in human liver carcinom...