In India, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. No systemic study has been done on protective effect of Cucumis trigonus Roxb. (Cucurbitaceae) to treat hepatic diseases. Protective action of C. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

Many hepatoprotective herbal preparations have been recommended in alternative systems of medicine for the treatment of hepatic disorders. No systematic study has been done on protective efficacy of Capparis spinosa (Capparidaceae) to treat hepatic diseases. Protective action of C. spinosa ethanolic root bark extract was evaluated in this study in an animal model of hepatotoxicity, which was in...

The activities of several enzymes possibly implicated in lipogenesis were measured in the soluble fraction of homogenates of liver and adipose tissue of embryonic and growing chicks. The activities of adipose-tissue enzymes showed little or no change. The activities of hepatic hexose monophosphate-shunt dehydrogenases, malate dehydrogenase, 3-phosphoglyceraldehyde dehydrogenase and NAD-linked a...

Background: Besides acute lethal cyanide poisoning, its chronic intoxication may also produce some pathologic effects on different tissues that precedes alterations in biochemical parameters. The present study was aimed to evaluate the effects of sublethal cyanide exposure on some tissue enzyme activities in liver and kidney of rats. Methods: Twelve male rats were divided into two groups as ...

A large number of chemical agents, administered for therapeutic or diagnostic purposes, can produce various types of hepatic injury by several mechanisms. Some agents are intrinsically hepatotoxic, and others produce hepatic injury only in the rare, uniquely susceptible individual. Idiosyncrasy of the host is the mechanism for most types of drug-induced hepatic injury. It may reflect allergy to...

When rats adapted to a stock diet were fed on various high-carbohydrate diets, the hepatic activities of glucose-6-phosphate dehydrogenase, malic enzyme and acetyl-CoA carboxylase were more greatly increased by fructose than by any other carbohydrate. Even in the diabetic state, the enzyme activities were somewhat increased by fructose feeding. After feeding on the diets for 9 days, the hepatic...

To investigate the associations between obesity and serum hepatic enzyme activities, we measured total body fat (TBF), body mass index (BMI), and hepatic biochemical parameters in 732 apparently healthy adults. TBF was assessed using a body fat analyzer. Serum activities of alanine and aspartate aminotransferase (ALT and AST), gamma-glutamyl transferase (GGT), alkaline phosphatase (ALP), and la...

in india, a number of medicinal plants and their formulations are used to cure hepatic disorders in traditional systems of medicine. no systemic study has been done on protective effect of cucumis trigonus roxb. (cucurbitaceae) to treat hepatic diseases. protective action of c. trigonus fruit extracts was evaluated in this study in animal model of hepatotoxicity, which was induced by carbon tet...

background: besides acute lethal cyanide poisoning, its chronic intoxication may also produce some pathologic effects on different tissues that precedes alterations in biochemical parameters. the present study was aimed to evaluate the effects of sublethal cyanide exposure on some tissue enzyme activities in liver and kidney of rats. methods: twelve male rats were divided into two groups as fol...

Objective(s): Particularly in developing countries, selenium and/or iodine deficiencies are encountered and use of pesticides in agriculture are not well-controlled. Fenvalerate is a pyrethroid insectide used in agriculture and has applications against a wide range of pests. This study was designed to evaluate the effects of fenvalerate on hepatic and cerebral xenobiotic metabolizing enzyme act...