The purpose of this study was to examine the acute and sub-acute effects of diazinon onhistopathological parameters of liver tissue and blood level of hepatic enzymes of male commonfrog (Rana ridibunda). Frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):control and treatment groups with 30, 60, 90 and 120 μg/L diazinon in water for one day or oneweek. Hepatic enzymes containi...

Background and Aim: Cancer stem cells (CSCs) have been proposed as a driving force of tumor initiation, dissemination drug resistance. The protease inhibitor SerpinB3 (SB3) has involved in the early events hepatocarcinogenesis, is highly expressed hepatic progenitor cells. However, only limited information on possible role SB3 cholangiocarcinoma (CCA) stem-like compartment available.

In article number 2007425, Junmin Lee, Ali Khademhosseini, and co-workers present a breakthrough for modeling of non-alcoholic fatty liver disease (NAFLD) based on bioengineered multicellular microtissues liver-on-a-chip system. The consisting four major cell types (primary human hepatocytes, stellate cells, Kupffer endothelial cells) recapitulate the pathogenesis hepatic fibrosis driven by NAF...

neuroendocrine cells are of the peptide and amine secreting cells and because of endodermal origin, exist in respiratory and gastrointestinal system. the report confirms the presence of a tumor using immunohistochemical methods. a hepatic mass was detected in a 10-year-old male mixed–breed dog which was referred with clinical history of frequent vomiting, anorexia, lethargy and syncope. biochem...

introduction and objective: liver is an important body organ without which life is impossible. cyclophosphamide is an alkylating agent widely used as an anti-cancer (“antineoplastic” or “cytotoxic”) chemotherapy drug. the present study aimed to find a suitable antioxidant and examine the effect of vitamin e and selenium on reducing the side effects of cyclophosphamide on liver as a vital organ....

the purpose of this study was to examine the acute and sub-acute effects of diazinon onhistopathological parameters of liver tissue and blood level of hepatic enzymes of male commonfrog (rana ridibunda). frogs were assigned to 9 groups (n=8, meaning 8 frogs in each group):control and treatment groups with 30, 60, 90 and 120 μg/l diazinon in water for one day or oneweek. hepatic enzymes containi...

Introduction Dendritic cells (DCs) are bone marrow-derived cells, which migrate to lymphoid and non-lymphoid organs via blood. Liver DCs are believed to play an important role in the regulation of hepatic allograft acceptance. However, because of inherent difficulties in isolating adequate numbers of DCs from liver, limited information is available on the phenotype and functions of liver DCs. ...